Finally--you're managing to get cites in. Sorta.
Anyway, might as well post the full abstract below. Otherwise, who
knows what you're trying to say with a snippet. Of course, people that
don't progress don't need ARV. But 38% did use AZT but didn't develop
AIDS. Good point! Duesberg and Lauritsen are full of shit.
And notice the last sentence. Great citation. Thanks, Paul.
George M. Carter
On Sat, 02 Oct 2004 18:51:41 -0400, "PaulKing"
<aimulti@aimultimedia.com> wrote:
**
AIDS. 1994 Aug;8(8):1123-8. Related Articles, Links
Comment in:
AIDS. 1994 Aug;8(8):1179-82.
Long-term HIV-1 infection without immunologic progression.
Buchbinder SP, Katz MH, Hessol NA, O'Malley PM, Holmberg SD.
AIDS Office, Department of Public Health, San Francisco, California
94102.
OBJECTIVE: To identify and describe a subgroup of men infected with
HIV for 10-15 years without immunologic progression, and to evaluate
the effect of sexually transmitted diseases (STD) and recreational
drug use on delayed HIV disease progression. DESIGN: Inception cohort
study. SETTING: Municipal STD clinic. PARTICIPANTS: A total of 588 men
with well documented dates of HIV seroconversion and 197
HIV-seronegative controls. MAIN OUTCOME MEASURES: AIDS, CD4+ count,
rate of CD4+ cell loss, CD8+ count, beta 2-microglobulin, complete
blood count, p24 antigen and HIV-related symptoms. RESULTS: Of 588
men, 69% had developed AIDS by 14 years after HIV seroconversion (95%
confidence interval, 64-73%). Of 539 men with HIV seroconversion dates
prior to 1983, 42 men (8%) were healthy long-term HIV-positives (HLP),
HIV-infected > or = 10 years without AIDS and with CD4+ counts > 500 x
10(6)/l. When compared with progressors (men with HIV seroconversion
prior to 1983 but with AIDS or CD4+ counts < 200 x 10(6)/l), HLP had a
significantly slower rate of CD4+ decline (6 versus 85 x 10(6)/l
cells/year), and less abnormal immunologic, hematologic and clinical
parameters. However, when compared with HIV-uninfected controls, HLP
demonstrated lower CD4+ counts and mild hematologic abnormalities.
There were no consistent differences between HLP and progressors in
prior exposure to recreational drugs or STD. CONCLUSION: There are
individuals with long-term HIV infection who appear clinically and
immunologically healthy 10-15 years after HIV seroconversion, with
stable CD4+ counts. Lack of exposure to STD or recreational drugs does
not appear to explain the delayed course of disease progression in
HLP.
