- New HIV drug shows promise
- Posted by spamhotmail
http://www.cbc.ca/health/story/2007/04/04/hiv-drug.html
New HIV drug shows promise
Last Updated: Wednesday, April 4, 2007 | 6:55 PM ET
CBC News
For people with advanced HIV infections, a new drug seems to suppress
the virus better than existing treatments.
Antiviral drugs called protease inhibitors have been the gold standard
for treating HIV since the mid-1990s, but the virus is becoming
increasingly resistant.
The new drug, darunavir, also called Prezista, is like other protease
inhibitors designed to lock up an enzyme that the virus needs to make
more copies of itself.
In the study, researchers studied 100 people who took darunavir in
combination with a low dose of an older protease inhibitor called
ritonavir, and a control group of 120 people who took an existing
combination therapy.
People in both groups had advanced HIV infection and their current
therapies were failing, said Dr. Bonaventura Clotet of Barcelona and
colleagues in an upcoming issue of the medical journal the Lancet.
About 45 per cent of those taking darunavir-ritonavir showed the
lowest recordable level of HIV genetic material in their blood
compared with 10 per cent in the control group.
Continue Article
People taking darunavir-ritonavir also showed an increase in the
immune system's CD4 cells that was five times higher than among those
in the other group (19 cells per microlitre versus 102 cells per
microlitre).
Doctors use the amount of HIV in the blood, or viral load, and the
levels of infection-fighting CD4 cells to track progression to AIDS
and to measure if antiretroviral therapy is working.
New option for HIV resistance
To prove darunavir works, patients will need to be tracked, ideally
for another two or three years, said Dr. Rodger MacArthur, of Wayne
State University in Detroit, in a journal commentary.
"For now, all of us treating HIV-infected individuals in clinical
practice will probably rejoice in the availability of darunavir, since
it seems to be a safe, well-tolerated, and truly effective agent
against multi-drug resistant HIV," MacArthur wrote.
Darunavir-ritonavir also needs to be compared with an existing
therapy, tipranavir-ritonavir, since resistance to one could fuel
resistance to the other.
The virus mutates quickly and may resist medications, especially if
drug regimens are not followed closely.
Failure rates for antiretroviral drugs range from 21 per cent among
patients already taking the medications to 11 per cent in those just
starting treatment, the researchers said.
Prezista is approved for sale by the U.S. Food and Drug
Administration, and with conditions by Health Canada and European
regulators.
At the International AIDS Conference in Toronto in 2006, researchers
reported early results of a new class of drugs, called integrase
inhibitors, that stop the genetic material's ability to integrate with
the host chromosome.
Integrase inhibitors would tackle the third and final step that HIV
undergoes to copy itself.
- Posted by spamhotmail
http://www.cbc.ca/health/story/2007/04/04/hiv-drug.html
New HIV drug shows promise
Last Updated: Wednesday, April 4, 2007 | 6:55 PM ET
CBC News
For people with advanced HIV infections, a new drug seems to suppress
the virus better than existing treatments.
Antiviral drugs called protease inhibitors have been the gold standard
for treating HIV since the mid-1990s, but the virus is becoming
increasingly resistant.
The new drug, darunavir, also called Prezista, is like other protease
inhibitors designed to lock up an enzyme that the virus needs to make
more copies of itself.
In the study, researchers studied 100 people who took darunavir in
combination with a low dose of an older protease inhibitor called
ritonavir, and a control group of 120 people who took an existing
combination therapy.
People in both groups had advanced HIV infection and their current
therapies were failing, said Dr. Bonaventura Clotet of Barcelona and
colleagues in an upcoming issue of the medical journal the Lancet.
About 45 per cent of those taking darunavir-ritonavir showed the
lowest recordable level of HIV genetic material in their blood
compared with 10 per cent in the control group.
Continue Article
People taking darunavir-ritonavir also showed an increase in the
immune system's CD4 cells that was five times higher than among those
in the other group (19 cells per microlitre versus 102 cells per
microlitre).
Doctors use the amount of HIV in the blood, or viral load, and the
levels of infection-fighting CD4 cells to track progression to AIDS
and to measure if antiretroviral therapy is working.
New option for HIV resistance
To prove darunavir works, patients will need to be tracked, ideally
for another two or three years, said Dr. Rodger MacArthur, of Wayne
State University in Detroit, in a journal commentary.
"For now, all of us treating HIV-infected individuals in clinical
practice will probably rejoice in the availability of darunavir, since
it seems to be a safe, well-tolerated, and truly effective agent
against multi-drug resistant HIV," MacArthur wrote.
Darunavir-ritonavir also needs to be compared with an existing
therapy, tipranavir-ritonavir, since resistance to one could fuel
resistance to the other.
The virus mutates quickly and may resist medications, especially if
drug regimens are not followed closely.
Failure rates for antiretroviral drugs range from 21 per cent among
patients already taking the medications to 11 per cent in those just
starting treatment, the researchers said.
Prezista is approved for sale by the U.S. Food and Drug
Administration, and with conditions by Health Canada and European
regulators.
At the International AIDS Conference in Toronto in 2006, researchers
reported early results of a new class of drugs, called integrase
inhibitors, that stop the genetic material's ability to integrate with
the host chromosome.
Integrase inhibitors would tackle the third and final step that HIV
undergoes to copy itself.
- Posted by spamhotmail
spamhotmail wrote:
Hi, I'm the moderator of soc.support.aids-hiv+. I've broadened the
charter from just support to include postings like these, if you'd
like
to submit it.
We'll accept just about anything poz-related, except for
denialist/dissident posts. I would prefer someone had a comment
about
why they were posting articles like this, rather than just
cut-and-paste, though.
Thanks.
Moderator, soc.support.aids-hiv+
Hi sorry for posting it
it is good info
it post it 2 times too so sorry.
I dont know google dos it that way.
thanks
- Posted by Brian Mailman
spamhotmail wrote:
This group is misc.health.aids.
I was suggesting you post in soc.support.aids-hiv+, a different group.
B/
- Posted by HIV Positive
On 4 Apr 2007 18:38:58 -0700, "spamhotmail" <spamhotmail@yahoo.com>
wrote:
I don't think anything about HIV can be described as 'gold standard.'
The whole theories of HIV and AIDS are based on very unstable
foundations.
So one group took one set of deadly drugs, and the control group took
another set of deadly drugs? I think I've heard this one before:
don't tell me... is one set of deadly drugs shown to be slightly less
toxic than the other by any chance?
Aha, at last. Someone has admitted the HIV treatments fail. Well,
that's a start I suppose.
Erm, so what is this trying to tell us? 10% of the 'control' group,
whose lethal drug cocktail was failing, still manage to have
undetectable viral load?
Oh well, at least he still has an open mind about it. 
Oh yes, that old trick. For a 'virus' that has a very basic
composition, HIV is very clever.
To nearer 100% if you include those who die.
--
URL: http://hiv.positive.googlepages.com/
Moible: +447939991519
- Posted by GMCarter
On Sat, 07 Apr 2007 18:28:40 +0100, "HIV Positive"
<hiv.positive@gmail.com> wrote:
LOL...bullshit. What a profound expression of your abject ignorance.
You'll be dead soon enough.
- Posted by HIV Positive
On Sun, 08 Apr 2007 11:27:12 GMT, GMCarter <fiar@verizon.net> wrote:
LOL. Am I messing up your HIV=AIDS=Death statistics?
It's very unkind to wish someone death simply because they don't fit
into your theory or agree with your point of view.
I'm sure you'll be pleased to learn that my death may not be too far
off. I've been suffering from depressions that's been steadily
getting worse for some time now. So at my own hand your wish may soon
come true, however my death won't be another statistic to add to your
argument.
--
URL: http://hiv.positive.googlepages.com/
Moible: +447939991519
- Posted by GMCarter
On Sun, 08 Apr 2007 13:30:51 +0100, "HIV Positive"
<hiv.positive@gmail.com> wrote:
LOL...no, you're messing with your own head.
- Posted by RocketScience
On Apr 8, 7:27 am, GMCarter <f...@verizon.net> wrote:
Important video relating to HIV and AIDS.
http://www.aidsfraudvideo.com/
HIV=AIDS: Fact or Fraud? One of the most powerful video documentaries
of our time boldly reveals the modern medical-industrial complex's
dire descent into utter corruption. This feature-length expose
explains exactly how the 300-Billion-dollar AID$ fraud began, why HIV
can NOT be the cause of AIDS, what the real causes could be, and who
manipulates the public's good intentions while poisoning hundreds of
thousands with toxic drugs that cause the very disease they are
supposed to prevent. This is a systematic dissection of the HIV/AID$
machine and how they hijacked a program designed to fight a worldwide
plight of human suffering and drove it down the road to hell. Yet this
program offers hope, inspired by the courage and articulate arguments
of a group of growing voices internationally challenging the
HIV=AIDS=DEATH hysteria. A MUST SEE for anyone interested in truly
understanding the facts about HIV/AID$.
You will meet a number of highly reputable scientists who all agree
that HIV doesn't cause AIDS, including Dr. Peter Duesberg, who was the
first scientist to map the genetic structure of retroviruses. He is
joined by Nobel Prize winners Dr. Kary Mullis and Dr.Walter Gilbert,
along with Dr. David Rasnick, an expert in the field of protease
inhibitors
Is HIV/AIDS the golden idol of junk science? Judge for yourself.
Professionally produced, written and researched, acclaimed by
physicians, scientists, journalists and humanitarians internationally,
this is the video encyclopedia of HIV/AIDS dissident movement! THE
defining documentary on the HIV/AIDS fraud
rocketscience
- Posted by GMCarter
On 4 Apr 2007 18:38:58 -0700, "spamhotmail" <spamhotmail@yahoo.com>
wrote:
Is this like HEAL Toronto? Oh. No. Most of them died of AIDS.
