- Factors Known to Cause False Positive HIV Antibody Test Results
- Posted by PaulKing
+Factors Known to Cause
False Positive HIV Antibody Test Results
1.Anti-carbohydrate antibodies 52,19,13
2.Naturally-occurring antibodies 5,19
3.Passive immunization: receipt of gamma globulin or immune (as
prophylaxis against infection which contains antibodies) 18, 26, 60, 4,
22, 42, 43, 13
4.Leprosy 2, 25
5.Tuberculosis 25
6.Mycobacterium avium 25
7.Systemic lupus erythematosus 15, 23
8.Renal (kidney) failure 48, 23, 13
9.Hemodialysis/renal failure 56, 16, 41, 10, 49
10.Alpha interferon therapy in hemodialysis patients 54
11.Flu 36
12.Flu vaccination 30, 11, 3, 20, 13, 43
13.Herpes simplex I 27
14.Herpes simplex II 11
15.Upper respiratory tract infection (cold or flu) 11
16.Recent viral infection or exposure to viral vaccines 11
17.Pregnancy in multiparous women 58, 53, 13, 43, 36
18.Malaria 6, 12
19.High levels of circulating immune complexes 6, 33
20.Hypergammaglobulinemia (high levels of antibodies) 40, 33
21.False positives on other tests, including RPR (rapid plasma
reagent) test for syphilis 17, 48, 33, 10, 49
22.Rheumatoid arthritis 36
23.Hepatitis B vaccination 28, 21, 40, 43
24.Tetanus vaccination 40
25.Organ transplantation 1, 36
26.Renal transplantation 35, 9, 48, 13, 56
27.Anti-lymphocyte antibodies 56, 31
28.Anti-collagen antibodies (found in gay men, haemophiliacs, Africans of
both sexes and people with leprosy) 31
29.Serum-positive for rheumatoid factor, antinuclear antibody (both found
in rheumatoid arthritis and other autoantibodies) 14, 62, 53
30.Autoimmune diseases 44, 29, 1O, 40, 49, 43
31.Systemic lupus erythematosus, scleroderma, connective tissue disease,
dermatomyositis Acute viral infections, DNA viral infections 59,
48, 43, 53, 40, 13
32.Malignant neoplasms (cancers) 40
33.Alcoholic hepatitis/alcoholic liver disease 32, 48, 40, 10, 13, 49, 43,
53
34.Primary sclerosing cholangitis 48, 53
35.Hepatitis 54
36."Sticky" blood (in Africans) 38, 34, 40
37.Antibodies with a high affinity for polystyrene (used in the test kits)
62, 40, 3
38.Blood transfusions, multiple blood transfusions 63, 36, 13, 49, 43, 41
39.Multiple myeloma 10, 43, 53
40.HLA antibodies (to Class I and II leukocyte antigens) 7, 46, 63, 48,
10, 13, 49, 43, 53
41.Anti-smooth muscle antibody 48
42.Anti-parietal cell antibody 48
43.Anti-hepatitis A IgM (antibody) 48
44.Anti-Hbc IgM 48
45.Administration of human immunoglobulin preparations pooled before 1985
10
46.Haemophilia 10, 49
47.Haematologic malignant disorders/lymphoma 43, 53, 9, 48, 13
48.Primary biliary cirrhosis 43, 53, 13, 48
49.Stevens-Johnson syndrome 9, 48, 13
50.Q-fever with associated hepatitis 61
51.Heat-treated specimens 51, 57, 24, 49, 48
52.Lipemic serum (blood with high levels of fat or lipids) 49
53.Haemolyzed serum (blood where haemoglobin is separated from red cells)
49
54.Hyperbilirubinemia 10, 13
55.Globulins produced during polyclonal gammopathies (which are seen in
AIDS risk groups) 10, 13, 48 cross-reactions 10
57.Normal human ribonucleoproteins 48, 13
58.Other retroviruses 8, 55, 14, 48, 13
59.Anti-mitochondrial antibodies 48, 13
60.Anti-nuclear antibodies 48, 13, 53
61.Anti-microsomal antibodies 34
62.T-cell leukocyte antigen antibodies 48, 13
63.Proteins on the filter paper 13
64.Epstein-Barr virus 37
65.Visceral leishmaniasis 45
66.Receptive anal sex 39, 64
Christine Johnson, a researcher and author, compiled this list of
conditions documented in the scientific literature to cause positives on
HIV tests, and provides references for each condition.
Christine notes:
"Just because something is on this list doesn't mean that it will
definitely, or even probably, cause a false-positive. It depends on what
antibodies the individual carries as well as the characteristics of each
particular test kit.
For instance, some, but not all people who have had blood transfusions,
prior pregnancies or an organ transplant will make HLA antibodies. And
some, but not all test kits (both ELISA and Western blot) will be
contaminated with HLA antigens to which these antibodies can react. Only
if these two conditions coincide might you get a false-positive due to HLA
cross-reactivity.
There are conditions that are more likely than others to cause
false-positives. And there are some conditions that we aren't aware of yet
which may be documented in the future to cause false-positives. Some of
the factors on the list have been documented only for ELISA, while some
have been documented for both ELISA and Western blot (WB) tests.
People may be eager to argue that if a factor is only known to cause
false-positives on ELISA, this problem won't be carried over to the WB.
But remember, a WB is positive by virtue of accumulating enough individual
positive bands to add up to the total required by whatever criteria is
used to interpret it 39. So the more exposure a person has had to foreign
antigens, proteins and infectious agents, the more various antibodies he
or she will have in their system, and the more likely it is
that there will be several cross-reacting antibodies, enough to make the
WB positive.
It is to be noted that all AIDS risk groups (and Africans as well), but
not the general US or Western European population, have this problem in
common: they have been exposed to a plethora of foreign antigens and
proteins. This is why people in the AIDS "risk groups" tend to have
positive WBs (i.e., to be considered "HIV-infected") and people in the
population don't. However, even people in low-risk populations have
false-positive Western blots for poorly understood reasons 47.
Since false-positives to every single HIV protein have been documented 36,
how do we know if the positive WB bands represent the various proteins to
HIV, or a collection of false-positive bands reacting to several different
non-HIV antibodies?"
- Posted by PaulKing
+Factors Known to Cause
False Positive HIV Antibody Test Results
1.Anti-carbohydrate antibodies 52,19,13
2.Naturally-occurring antibodies 5,19
3.Passive immunization: receipt of gamma globulin or immune (as
prophylaxis against infection which contains antibodies) 18, 26, 60, 4,
22, 42, 43, 13
4.Leprosy 2, 25
5.Tuberculosis 25
6.Mycobacterium avium 25
7.Systemic lupus erythematosus 15, 23
8.Renal (kidney) failure 48, 23, 13
9.Hemodialysis/renal failure 56, 16, 41, 10, 49
10.Alpha interferon therapy in hemodialysis patients 54
11.Flu 36
12.Flu vaccination 30, 11, 3, 20, 13, 43
13.Herpes simplex I 27
14.Herpes simplex II 11
15.Upper respiratory tract infection (cold or flu) 11
16.Recent viral infection or exposure to viral vaccines 11
17.Pregnancy in multiparous women 58, 53, 13, 43, 36
18.Malaria 6, 12
19.High levels of circulating immune complexes 6, 33
20.Hypergammaglobulinemia (high levels of antibodies) 40, 33
21.False positives on other tests, including RPR (rapid plasma
reagent) test for syphilis 17, 48, 33, 10, 49
22.Rheumatoid arthritis 36
23.Hepatitis B vaccination 28, 21, 40, 43
24.Tetanus vaccination 40
25.Organ transplantation 1, 36
26.Renal transplantation 35, 9, 48, 13, 56
27.Anti-lymphocyte antibodies 56, 31
28.Anti-collagen antibodies (found in gay men, haemophiliacs, Africans of
both sexes and people with leprosy) 31
29.Serum-positive for rheumatoid factor, antinuclear antibody (both found
in rheumatoid arthritis and other autoantibodies) 14, 62, 53
30.Autoimmune diseases 44, 29, 1O, 40, 49, 43
31.Systemic lupus erythematosus, scleroderma, connective tissue disease,
dermatomyositis Acute viral infections, DNA viral infections 59,
48, 43, 53, 40, 13
32.Malignant neoplasms (cancers) 40
33.Alcoholic hepatitis/alcoholic liver disease 32, 48, 40, 10, 13, 49,
43,
53
34.Primary sclerosing cholangitis 48, 53
35.Hepatitis 54
36."Sticky" blood (in Africans) 38, 34, 40
37.Antibodies with a high affinity for polystyrene (used in the test
kits)
62, 40, 3
38.Blood transfusions, multiple blood transfusions 63, 36, 13, 49, 43, 41
39.Multiple myeloma 10, 43, 53
40.HLA antibodies (to Class I and II leukocyte antigens) 7, 46, 63, 48,
10, 13, 49, 43, 53
41.Anti-smooth muscle antibody 48
42.Anti-parietal cell antibody 48
43.Anti-hepatitis A IgM (antibody) 48
44.Anti-Hbc IgM 48
45.Administration of human immunoglobulin preparations pooled before 1985
10
46.Haemophilia 10, 49
47.Haematologic malignant disorders/lymphoma 43, 53, 9, 48, 13
48.Primary biliary cirrhosis 43, 53, 13, 48
49.Stevens-Johnson syndrome 9, 48, 13
50.Q-fever with associated hepatitis 61
51.Heat-treated specimens 51, 57, 24, 49, 48
52.Lipemic serum (blood with high levels of fat or lipids) 49
53.Haemolyzed serum (blood where haemoglobin is separated from red cells)
49
54.Hyperbilirubinemia 10, 13
55.Globulins produced during polyclonal gammopathies (which are seen in
AIDS risk groups) 10, 13, 48 cross-reactions 10
57.Normal human ribonucleoproteins 48, 13
58.Other retroviruses 8, 55, 14, 48, 13
59.Anti-mitochondrial antibodies 48, 13
60.Anti-nuclear antibodies 48, 13, 53
61.Anti-microsomal antibodies 34
62.T-cell leukocyte antigen antibodies 48, 13
63.Proteins on the filter paper 13
64.Epstein-Barr virus 37
65.Visceral leishmaniasis 45
66.Receptive anal sex 39, 64
Christine Johnson, a researcher and author, compiled this list of
conditions documented in the scientific literature to cause positives on
HIV tests, and provides references for each condition.
Christine notes:
"Just because something is on this list doesn't mean that it will
definitely, or even probably, cause a false-positive. It depends on what
antibodies the individual carries as well as the characteristics of each
particular test kit.
For instance, some, but not all people who have had blood transfusions,
prior pregnancies or an organ transplant will make HLA antibodies. And
some, but not all test kits (both ELISA and Western blot) will be
contaminated with HLA antigens to which these antibodies can react. Only
if these two conditions coincide might you get a false-positive due to
HLA
cross-reactivity.
There are conditions that are more likely than others to cause
false-positives. And there are some conditions that we aren't aware of
yet
which may be documented in the future to cause false-positives. Some of
the factors on the list have been documented only for ELISA, while some
have been documented for both ELISA and Western blot (WB) tests.
People may be eager to argue that if a factor is only known to cause
false-positives on ELISA, this problem won't be carried over to the WB.
But remember, a WB is positive by virtue of accumulating enough
individual
positive bands to add up to the total required by whatever criteria is
used to interpret it 39. So the more exposure a person has had to foreign
antigens, proteins and infectious agents, the more various antibodies he
or she will have in their system, and the more likely it is
that there will be several cross-reacting antibodies, enough to make the
WB positive.
It is to be noted that all AIDS risk groups (and Africans as well), but
not the general US or Western European population, have this problem in
common: they have been exposed to a plethora of foreign antigens and
proteins. This is why people in the AIDS "risk groups" tend to have
positive WBs (i.e., to be considered "HIV-infected") and people in the
population don't. However, even people in low-risk populations have
false-positive Western blots for poorly understood reasons 47.
Since false-positives to every single HIV protein have been documented
36,
how do we know if the positive WB bands represent the various proteins to
HIV, or a collection of false-positive bands reacting to several
different
non-HIV antibodies?"
- Posted by GMCarter
On Tue, 15 Feb 2005 23:31:30 -0500, "PaulKing"
<aimulti@aimultimedia.com> wrote:
Bennett previously and at length responded to this old list that you
continue to regurgitate despite the fact that it is mostly a load of
crap. Mark, you are the most wretched liar. I'm not saying that to
just name call (altho gosh that's fun!!) but simply because it's true.
George M. Carter
- Posted by PaulKing
You have been proven to be the lier.
This list is all correct as you well know.
Paul but you an call me Mark if you so wish.
- Posted by Gary Stein
"PaulKing" <aimulti@aimultimedia.com> wrote in message
news:a9dfb4ce7ab2e30a8d2901be12a60162@localhost.ta lkabouthealthnetwork.com...
What Giraldo neatly ignores is that all of the quality control, all
the assements of specificity and sensitivity, the tests of inter-
and intra-measure variation, are all done on the test as it is intended
to be used. So he was able to generate some anolous results by misusing
the test. What does this prove? On important point to remember is
that these tests are _NOT_ approved based on theory. There are stringent
and detailed criteria in regards to the actual _FUNCTION_ of the
test that are required. Whether the denialists like it or no, these
tests have been validated, calibrated, and quality controlled using
specimens of known HIV status. And by "known HIV status", I do _not_
mean that EIA is validated by use of EIA. Theres's some very compelling
work with HIV Cultures.
"Performance characteristics of serologic tests for human
immunodeficiency virus type 1 (HIV-1) antibody among Minnesota blood
donors. Public health and clinical implications." MacDonald KL, Jackson
JB, Bowman RJ, Polesky HF, Rhame FS, Balfour HH Jr, Osterholm MT Ann
Intern Med. 1989 Apr 15;110(8):617-21.
"Human immunodeficiency virus type 1 detected in all seropositive
symptomatic and asymptomatic individuals" Jackson JB, Kwok SY, Sninsky
JJ, Hopsicker JS, Sannerud KJ, Rhame FS, Henry K, Simpson M, Balfour HH
Jr J Clin Microbiol. 1990 Jan;28(1):16-9.
- Posted by PaulKing
Factors Known to Cause
False Positive HIV Antibody Test Results
1.Anti-carbohydrate antibodies 52,19,13
2.Naturally-occurring antibodies 5,19
3.Passive immunization: receipt of gamma globulin or immune (as
prophylaxis against infection which contains antibodies) 18, 26, 60, 4,
22, 42, 43, 13
4.Leprosy 2, 25
5.Tuberculosis 25
6.Mycobacterium avium 25
7.Systemic lupus erythematosus 15, 23
8.Renal (kidney) failure 48, 23, 13
9.Hemodialysis/renal failure 56, 16, 41, 10, 49
10.Alpha interferon therapy in hemodialysis patients 54
11.Flu 36
12.Flu vaccination 30, 11, 3, 20, 13, 43
13.Herpes simplex I 27
14.Herpes simplex II 11
15.Upper respiratory tract infection (cold or flu) 11
16.Recent viral infection or exposure to viral vaccines 11
17.Pregnancy in multiparous women 58, 53, 13, 43, 36
18.Malaria 6, 12
19.High levels of circulating immune complexes 6, 33
20.Hypergammaglobulinemia (high levels of antibodies) 40, 33
21.False positives on other tests, including RPR (rapid plasma
reagent) test for syphilis 17, 48, 33, 10, 49
22.Rheumatoid arthritis 36
23.Hepatitis B vaccination 28, 21, 40, 43
24.Tetanus vaccination 40
25.Organ transplantation 1, 36
26.Renal transplantation 35, 9, 48, 13, 56
27.Anti-lymphocyte antibodies 56, 31
28.Anti-collagen antibodies (found in gay men, haemophiliacs, Africans of
both sexes and people with leprosy) 31
29.Serum-positive for rheumatoid factor, antinuclear antibody (both found
in rheumatoid arthritis and other autoantibodies) 14, 62, 53
30.Autoimmune diseases 44, 29, 1O, 40, 49, 43
31.Systemic lupus erythematosus, scleroderma, connective tissue disease,
dermatomyositis Acute viral infections, DNA viral infections 59,
48, 43, 53, 40, 13
32.Malignant neoplasms (cancers) 40
33.Alcoholic hepatitis/alcoholic liver disease 32, 48, 40, 10, 13, 49, 43,
53
34.Primary sclerosing cholangitis 48, 53
35.Hepatitis 54
36."Sticky" blood (in Africans) 38, 34, 40
37.Antibodies with a high affinity for polystyrene (used in the test kits)
62, 40, 3
38.Blood transfusions, multiple blood transfusions 63, 36, 13, 49, 43, 41
39.Multiple myeloma 10, 43, 53
40.HLA antibodies (to Class I and II leukocyte antigens) 7, 46, 63, 48,
10, 13, 49, 43, 53
41.Anti-smooth muscle antibody 48
42.Anti-parietal cell antibody 48
43.Anti-hepatitis A IgM (antibody) 48
44.Anti-Hbc IgM 48
45.Administration of human immunoglobulin preparations pooled before 1985
10
46.Haemophilia 10, 49
47.Haematologic malignant disorders/lymphoma 43, 53, 9, 48, 13
48.Primary biliary cirrhosis 43, 53, 13, 48
49.Stevens-Johnson syndrome 9, 48, 13
50.Q-fever with associated hepatitis 61
51.Heat-treated specimens 51, 57, 24, 49, 48
52.Lipemic serum (blood with high levels of fat or lipids) 49
53.Haemolyzed serum (blood where haemoglobin is separated from red cells)
49
54.Hyperbilirubinemia 10, 13
55.Globulins produced during polyclonal gammopathies (which are seen in
AIDS risk groups) 10, 13, 48 cross-reactions 10
57.Normal human ribonucleoproteins 48, 13
58.Other retroviruses 8, 55, 14, 48, 13
59.Anti-mitochondrial antibodies 48, 13
60.Anti-nuclear antibodies 48, 13, 53
61.Anti-microsomal antibodies 34
62.T-cell leukocyte antigen antibodies 48, 13
63.Proteins on the filter paper 13
64.Epstein-Barr virus 37
65.Visceral leishmaniasis 45
66.Receptive anal sex 39, 64
Christine Johnson, a researcher and author, compiled this list of
conditions documented in the scientific literature to cause positives on
HIV tests, and provides references for each condition.
Christine notes:
"Just because something is on this list doesn't mean that it will
definitely, or even probably, cause a false-positive. It depends on what
antibodies the individual carries as well as the characteristics of each
particular test kit.
For instance, some, but not all people who have had blood transfusions,
prior pregnancies or an organ transplant will make HLA antibodies. And
some, but not all test kits (both ELISA and Western blot) will be
contaminated with HLA antigens to which these antibodies can react. Only
if these two conditions coincide might you get a false-positive due to HLA
cross-reactivity.
There are conditions that are more likely than others to cause
false-positives. And there are some conditions that we aren't aware of yet
which may be documented in the future to cause false-positives. Some of
the factors on the list have been documented only for ELISA, while some
have been documented for both ELISA and Western blot (WB) tests.
People may be eager to argue that if a factor is only known to cause
false-positives on ELISA, this problem won't be carried over to the WB.
But remember, a WB is positive by virtue of accumulating enough individual
positive bands to add up to the total required by whatever criteria is
used to interpret it 39. So the more exposure a person has had to foreign
antigens, proteins and infectious agents, the more various antibodies he
or she will have in their system, and the more likely it is
that there will be several cross-reacting antibodies, enough to make the
WB positive.
It is to be noted that all AIDS risk groups (and Africans as well), but
not the general US or Western European population, have this problem in
common: they have been exposed to a plethora of foreign antigens and
proteins. This is why people in the AIDS "risk groups" tend to have
positive WBs (i.e., to be considered "HIV-infected") and people in the
population don't. However, even people in low-risk populations have
false-positive Western blots for poorly understood reasons 47.
Since false-positives to every single HIV protein have been documented 36,
how do we know if the positive WB bands represent the various proteins to
HIV, or a collection of false-positive bands reacting to several different
non-HIV antibodies?"
- Posted by GMCarter
On Sat, 07 May 2005 17:42:24 -0400, "PaulKing"
<aimulti@aimultimedia.com> wrote:
This was reviewed and found to be riddled with errors and nonsense.
You do not cite the original source, of course, which is from 1996.
Repeatedly cited, repeatedly refuted. Repeatedly reposted by Mark
without EVER being able to comment on the extensive refutations.
Not to say that some conditions won't cause a false positive. This
happens with EVERY diagnostic test. ALL of them. And HIV tests have a
high specificity and sensitivity.
George M. Carter
- Posted by PaulKing
"This was reviewed"
What utter nonsense. Who reviewed it?
You?
- Posted by PaulKing
"And HIV tests have a
high specificity and sensitivity."
You know that is a COMPLETE lie.
- Posted by tsip29
hi, paul
who reviewed the list you are giving! can you also direct me to studys
that shows this !
also you have heard most of what is out there! can you tell me of studies
that have been done by dutch( =netherlands) resaerchers about hiv/aids.
- Posted by David Canzi -- non-mailable
In article <c449d8f81ba5467cc6cf21162d02c05d@localhost.talkab outhealthnetwork.com>,
PaulKing <aimulti@aimultimedia.com> wrote:
http://www.randi.org/research/index.html
--
David Canzi
- Posted by PaulKing
Your paranormal site link.
Well, if you believe in 'AIDS' I should have known you would believe in
the paranormal too.
You really do love nonsense.
- Posted by David Canzi -- non-mailable
In article <472281b28ca963b278d5164f1bf145a5@localhost.talkab outhealthnetwork.com>,
PaulKing <aimulti@aimultimedia.com> wrote:
Try reading enough of the site to find out what it's about.
Since you often claim to have telepathic powers, I thought you might
be interested in Randi's challenge.
--
David Canzi
- Posted by Gary Stein
"David Canzi -- non-mailable" <dmcanzi@remulak.ads.uwaterloo.ca> wrote in
message news:d5p2ep$pfd$1@rumours.uwaterloo.ca...
Paul read....you've got to be joking he has a hard enough time cutting and
pasting I doubt he spends much time actually reading. If he did he might
realize that he's totally wrong on just about every point he tries to make.
Gary Stein
- Posted by PaulKing
"Since you often claim to have telepathic powers"
I have NEVER claimed any such thing. I don't believe in such nonsense.
Do you lie about everything?
- Posted by PaulKing
"If he did he might realize that he's totally wrong on just about every
point he tries to
make."
Was that a typo? Did you mean 'every point you make?'
Yes I do see that you are a total idiot.
Thanks for making the point.
- Posted by David Canzi -- non-mailable
In article <bcb43281742c726915d8e637949f117f@localhost.talkab outhealthnetwork.com>,
PaulKing <aimulti@aimultimedia.com> wrote:
Here are three of your recent claims of telepathic power:
"You know the truth on this point"
"They are complete nonsense as you well know."
"You know that is a COMPLETE lie."
--
David Canzi
- Posted by Alex
"PaulKing" <aimulti@aimultimedia.com> schreef in bericht
news:c449d8f81ba5467cc6cf21162d02c05d@localhost.ta lkabouthealthnetwork.com...
And contradictory. Usually, specificity and sensitivity
are inversely correlated (you have one at the detriment
to the other - hence the use of [sensitive] screening tests
and [specific] confirmation tests). Or so the theory goes.
Alex
- Posted by GMCarter
On Tue, 10 May 2005 19:07:52 +0200, "Alex"
<avdeelen.REMOFETHIS@wanadoo.nl> wrote:
I would be delighted to see where you got this idea!
Doesn't seem to suggest that here:
http://www.cebm.utoronto.ca/glossary/spsn.htm
But it does go a way to explaining your typical statistical dithering.
George M. Carter
- Posted by David Canzi -- non-mailable
In article <cd9281lbdbrm3qok40tu5s3jcne3erip07@4ax.com>,
GMCarter <noway@nowherenospam.com> wrote:
Alex is what's known as a "statistical outliar".
--
David Canzi