27 Mechanisms involved in the anti-inflammatory effect of a
standardized willow bark extract.
Khayyal MT, El-Ghazaly MA, Abdallah DM, Okpanyi SN, Kelber O, Weiser D
Arzneimittelforschung. 2005; 55(11): 677-87

A standardized willow bark extract (STW 33-I) has been examined to
clarify its possible mechanism of action as an anti-inflammatory agent.
Various facets have been investigated in two inflammation models: the
6-day air pouch model in rats, representing the acute state and the
adjuvant induced arthritis representing the chronic one. Parameters
included leukocytic infiltration, levels of cytokines and prostanoids
in blood, and effects on cyclo-oxygenase (COX)-1 and/or COX-2 enzymes
as well as effects involving free radical production. The effect of the
extract was compared at two dose levels with comparable
anti-inflammatory doses of acetylsalicylic acid (CAS 50-78-2, ASA) as a
non-selective COX inhibitor, and celecoxib (CAS 169590-42-5) as a
selective COX-2 inhibitor. On a mg/kg basis, the extract was at least
as effective as ASA in reducing inflammatory exudates and in inhibiting
leukocytic infiltration as well as in preventing the rise in cytokines,
and was more effective than ASA in suppressing leukotrienes, but
equally effective in suppressing prostaglandins. On COX-2, STW 33-I was
more effective than ASA. The present findings show that STW 33-I
significantly raises GSH (reduced glutathione) levels, an effect which
helps to limit lipid peroxidation. The extract was more potent than
either ASA or celecoxib. Higher doses of the extract also reduced
malondialdehyde levels and raised shows definite superiority to either
ASA or celecoxib in protecting the body against oxidative stress. It is
therefore evident that STW 33-I is at least as active as ASA on all the
parameters of inflammatory mediators measured, when both are given on a
similar mg/kg dose. Considering, however, that the extract contains
only 24% salicin (molecular weight 286.2), while ASA has a molecular
weight of 180.3, it follows that on a molar basis of salicin vs
salicylate, the extract contains less than a sixth of the amount of
salicin as the amount of salicylate in ASA. Thus it appears that STW
33-I with its lower "salicin" content than an equivalent dose of ASA,
is at least as active as ASA on the measured parameters, a fact that
leads one to speculate that other constituents of the extract
contribute to its overall activity. The presence of polyphenols in STW
33-I probably plays a significant role in enhancing its free radical
scavenging properties. The fact that STW 33-I was superior to ASA in
this respect would suggest that the extract may have a better
anti-inflammatory effect than ASA on a weight to weight basis, with
possibly less side effects.

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore


DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

Tom,
Once again you forgot to mark your post "OT" for Off Topic.
Migraine pain is not caused by inflamation, so this info is definetly
off topic.

Also man is an omnivore not a herbivore and last but not least
if Jesus was a vegitarian why in the hell would he have fed the
multitude with fish MEAT.

Thanks for thinking of us, and have a Great Saturnalia
Bear

good stuff!
<ironjustice@aol.com> wrote in message
news:1135404615.349909.317790@z14g2000cwz.googlegr oups.com...

----- Original Message -----
From: "Bear" <bearsbugs@yahoo.com>
Newsgroups:
alt.support.arthritis,misc.health.arthritis,alt.su pport.crohns-colitis,alt.s
upport.headaches.migraine,alt.med.fibromyalgia
Sent: Saturday, December 24, 2005 3:36 AM
Subject: Re: Willow bark extract more potent than either ASA or celecoxib

Oops! I sent the following to Bear instead of ASHM...I'm always hitting
"Reply" instead of "Reply Group". Sorry Bear. Here it is again:

That's alright, Bear; it's good to hear from Tom (who loves us) now and
then. It has been at least 6 months since his last Epistle, and that's just
about the right interval. Besides, who can tell whether he is writing off
topic or not? Maybe Ken W can; he replied: "Good stuff" to Tom's post so I
guess he understands him. I wish I could; I have the nagging feeling that he
may be trying to tell us something important about life and the cosmos, but
I'm damned if I can sort it out.

Bobb







----== Posted via Newsfeeds.Com - Unlimited-Unrestricted-Secure Usenet News==----
http://www.newsfeeds.com The #1 Newsgroup Service in the World! 120,000+ Newsgroups
----= East and West-Coast Server Farms - Total Privacy via Encryption =----

Just because you have a .. migraine .. obviously makes you no .. expert
...

Heh .. heh ..

Headache and Migraine Drug Profiles: Celebrex, celecoxib
Celebrex, celecoxib: Facts about today's drugs used to treat migraine
and other
headaches.
headaches.about.com/library/meds/bl-neurontin.htm

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore


DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

Couldn't this cause severe bleeding for folk with Crohns and Colitis?

All salicylates share substantially the same side effects. The major adverse
effects include irritation of the gastric mucosa (a particular hazard to
individuals with ulcer disease)..........
John
<ironjustice@aol.com> wrote in message
news:1135404615.349909.317790@z14g2000cwz.googlegr oups.com...

KenW is in Usana (like Amway) he claims to have Crohns disease but have
cured it with his supplements:

http://groups.google.co.nz/group/alt...95db9e593b2cd3

John
"RKB" <nadacorvus@adacomp.net

http://www.organicfood.co.uk/vms/whitewillowbark.html

Unlike non-steroidal anti-inflammatory drugs (NSAIDs), the compound
salicin does not cause gastric or intestinal upset or bleeding as
aspirin can, this is because willow does not block prostaglandins in
the stomach or intestines.

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore


DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

I should have added the link (those weren't my words)
http://www.cfsan.fda.gov/~dms/ds-ill.html
John
<ironjustice@aol.com> wrote in message
news:1135471805.580328.312480@g44g2000cwa.googlegr oups.com...

John that info was from 13 years ago. 13 years ago they were against even
taking a multi-vitamin...My how times have changed within the FDA. about
180 degrees i would say.

For more recent information on Dietary Supplements
See http://www.cfsan.fda.gov/~dms/supplmnt.html


"John H" <89s@yahoo.com.au> wrote in message news:43ae0812@clear.net.nz...

You mean aspirin

Peter

The first time I was ill with crohns, I got sick of the pain and bodily
discomfort so I took a lot of asprin. Later I sat on the toilet and passed a
lot of red blood, I had to be given a blood, so this issue is a serious one.
You told me the link I presented is old (13 years)
Your link didn't point anywhere relevant but I searched the site and found
one that is 3 years old:

www.cfsan.fda.gov/~dms/fdsuppch.html
Herbal Ingredient: Willow bark
Possible Health Hazards: Reye syndrome, a potentially fatal disease
associated with aspirin intake in children with chickenpox or flu symptoms;
allergic reaction in adults. (Willow bark is marketed as an aspirin-free
product, although it actually contains an ingredient that converts to the
same active ingredient in aspirin.)
Can Usana confirm that it is o.k to take willow bark if you have IBD?
[Ken's in Usana..(like Amway) he claims to have beaten his crohns with his
supplements....google groups: KenW faq]
John
PS. the people with migranes wont want to read about Ken

"Ken.W" <phosgate@telus.net> wrote in message
news:A0rrf.11850$AP5.2498@edtnps84...

"John H" <89s@yahoo.com.au> wrote in message news:43aef621@clear.net.nz...
John not sure what this has to do with USANA...willow bark is not a nutrient
they have ever used.
Your trying to discredit usana with compareing it to Amway is just so far
off base as your assumption that they use willow bark. If your going to want
to argue a little knowledge about what you are trying to argue over
might be a good idea
Does Amway have there products listed in your doctors PDR? No!!
Did amway get listed #5 on Forbes list of best small companies?
Did Amway make number 3 on business weeks list of top-growth companies?
Did amway get top billing in "The Comparitive guide to
Nutritional Supplements?

Does amway stand behind a million dollar guarantee
against contaminants?
Was it amway that got rated #1 diributors choice for seven years running
when no other company ever got
2 years....by Network Marketing/mlm insider magazine.

Did there products get highlighted in Investors business daily,Shape, Self,
and Prevention?

Ken is a Usana "associate" (like Amway). He claims to have Crohns disease
and
to have controlled it with a "nutrient regime" of his Usana products.

Ken has no way of knowing whether this is true or not.


It is normal for Crohns sufferers to have bouts of the disease with
long/short periods of remission in between. The severity of individual cases
varies greatly from person to person.

Not everyone diagnosed with Crohns disease has to take meds.



Kens beliefs appear to be based on the writings of Dr Ray Strand author of
books such as "What Your Doctor Doesn't Know About Nutritional Medicine May
Be Killing You".



Dr Strand claims that Crohn's disease is one of over 70 chronic
degenerative diseases that are caused by oxidative stress. He recommends
large doses of (Usana) vitamins.


http://www.bionutrition.org/showSample.asp


Dr Strand who is is a family practitioner is on Usana's advisory board
.. He has never published a scientific paper in his career, or conducted a
scientific study. He has never earned any kind of degree in nutrition.


Dr Strands website allows associates to extract supplement treatments for
many diseases and this would give unqualified individuals an aura of medical
expertise which is essential for sales in the successful multi level
marketing of supplements.



While there are studies linking oxidative stress and Crohns. These have been
evaluated in medical journals and at medical symposiums and haven't (as
yet) led to anything beyond an adjunct treatment.



Here are some useful links:

Crohns And Colitis Foundation of America Diet and nutrition information.

http://www.ccfa.org/info/diet?LMI=4.2

Tufts University scientists on [quote] "various claims that taking large
doses of
antioxidants might help prevent a variety of chronic ailments."

http://enews.tufts.edu/stories/04170...neffective.htm

How the editorial board at Berkeley University came to their latest
recommendations on Vitamin E intake:

http://www.wellnessletter.com/html/ds/dsVitaminE.php



Linus Pauling Institute

http://lpi.oregonstate.edu/new/response.html





Kens assertions also appear to be based on the idea that his products are
superior, and references The Comparative Guide to Nutritional Supplements by
Lyle
Mac Williams.

Here's a link debunking the Comparative Guide as "little more than self
promotion by Usana":
http://www.melaleuca.com/wc/pdf/ComparativeGuide.pdf

[Lyle Mac William, who authored
the "Comparative Guide," says, in his own words, that there were only
TWO changes between the second and third edition:

--"the 3rd edition of our guide uses a median [rather than a mean]
value for each nutrient"

-- "we have increased the number of cited authorities to seven from the
previous four."]

[These are the people behind it

1. PHYLLIS BALCHER. Holds no academic position whatsoever. Only
credential: member of something called the "American Association of
Nutritional Consultants." The group accepts anyone willing to pay the
$150 entrance fee.

2. MICHAEL COLGAN. Has published one (1) scientific paper in his entire
career. Holds no academic position. Sells his own vitamins, tapes,
DVDs, books, newsletters, etc., at his traveling "seminars."

3. EARL MINDELL: A "professor" at something calling itself "Pacific
Western University." Address for this school: 1650 Westwood Blvd.,
Suite 205. (Must be a TINY university.)

4. MICHAEL MURRAY. A "professor" at something called "Bastryr
University," which awards degrees in "natural healing."

The campus was built as a seminary. Bastyr just leases it from the
Catholic Archdiocese of Seattle.


5. RICHARD PASSWATER: A "professor" at "Bernadean University." Address
for this school: 21757 Devonshire, Suite 16 (apparently another tiny
university).

6. RAY STRAND: Paid USANA promoter (officially: "member of USANA's
board of advisors"). What a coincidence: The "book" he contributes to
rates his company #1!

7. JULIAN WHITTAKER: Has created "a formula that has 17 ingredients
that help the eyes. It's called 'Vission Essentials,' and you can call
1-800..."]






Usana is a "Recruiting MLM"/ (essentially a pyramid scheme). Read this
article is from the
Desert News Utah:
http://deseretnews.com/dn/view/0,1249,600140269,00.html

[Usana admits (according to its SEC fillings) that 85% of its sales are to
other Usana Associates. The FDA recommends no more than 30%]


Is USANA a "Recruiting MLM," or Product-based Pyramid Scheme?
http://mlm-thetruth.com/Usana.htm



Scorin' with Orrin

How the gentleman from Utah made it easier for kids to buy steroids, speed,
and Spanish fly

http://www.washingtonmonthly.com/fea...mencimer2.html




From PR Watch. Political lobbying means supplements could pass on Mad Cow
disease.

http://www.prwatch.org/prwissues/1997Q3/swallow.html



Ken is backed by a down line and up line support crew and Usana's marketing
machine.
[Our on-line process:· Training - learn from the best Internet
communicators.
Learn how people "shake hands on the Internet" and apply their
techniques with your member sites.
You and your team can scrub prospects clean of prejudices and
misconceptions about Network Marketing with our optional ..]


An Comment on Usana stock from Smartmoney.com:

" Chief Executive Dave Wentz credited the strong results to associate
recruitment ..."



we are cautiously optimistic that Japan's new [general manager] will finally
drive the market forward," wrote Block in a July 21 research note. He calls
the stock "an excellent long-term investment" and notes that the most
important metric to watch is associate growth, since it's correlated so
closely with sales.



[85% of Sales are from one associate to another]
http://www.smartmoney.com/stockscree...=20040805intro





MLM Watch http://www.mlmwatch.org/

Quackwatch
http://www.quackwatch.org/

Consumerlab.com for objective testing of supplements
http://www.consumerlab.com/


What Usana is really about
http://cosmo_and_judy.usana.com/mystory_en.cfm



The Woolly Thinkers Guide to Rhetoric

http://www.butterfliesandwheels.com/rhetoric.php



Quotes by Ken:

"So why is so much more spent on research for the drugs?
It's definitly not because drugs have proved to be more effective in
treating our health problems. Aside from penicillin and being able to give
one a sexdrive...there hasn't been too many wonders in the drug world. yet
it consumes up most of the research money. Why is that?"



"Well if I understand correctly....DNA has proven that very little has to do
with genetics when it comes to our health."



"why you so worried about someone reading a book about a doctor who
recommends people taking vitamins? Especially when you haven't even read the
book....or is it my ten years without using meds got you all upset?"



Comparing the anti inflammatory drug Prednisone to Cigarettes:



"What would you call something that could eat away at your
joints,bones, cause diabetes, blindness, arthritis?
Heck...I call cigarretes a poison too What with it containing more than 50
known cancer causing agents.
But I can see they are still a big seller.



Oh come on Carole...Open your eyes
Sure they do!!!Why else would they give out meds that cause death? The most
recent being vioxx and boy did they ever dish it out!!
They spend a lot more time learning pharmacalogy then then do about how
nutrition works .In case you never heard this...but the pharmaceutical
companies play a huge part in there schooling. It use to be less then a
month out of there whole schooling was spent on nutrition. Nutrition is an
ongoing science that is just at it's infancy.
Just look at how volatile the DRI's are. Which use to be
the recommended daily allowances.





Do you know of a better company [than Usana ] Nina?
Just take a look at the ingredient list.... What wouldn't someone like about
it? I'm a firm believer that it's the best money can buy. Why wouldn't I
support it?

Nina there is a lot more to improving one's health than just dropping drugs
..You are extremely nieve to think that taking nutritonal supplements means
you just get to drop the meds. Thats just plain stupid...not too mention
dangerous.



Drugs are bad whether they are prescribed,
bought over the counter, or from the local pusher on the street....If one
can do with out them the better off he is in the long run.
Even with these maintenance dosages of drugs the disaesse will progress,
although it seems more slowly than one who just drops the meds .But that
person is usualyy not involved in a alternate way of treating the disease
either .I'm a firm beleiver that through
balanced Diet, along with complete and balanced quality supplements and
moderate exercise one can not only stp the progression of the disease but
can even repair some of the damage .........I'm an excelleent example and
i'm
definitly not alone in this...My stricture had gotten too the point over 5
years ago that I could no longer get solids in me and they wanted to chop it
out.. I have not puked up my food in over 5 years now do to that stricture
nor did i have the operation.

Ken scoffs at nutritional advice from Tufts University:



But what about one's eye health ? One needs over a thousand milligrams of
vitamin C to be effective there.
No wonder you don't pay for the advise...i don't think I would either.

"John H" <89s@yahoo.com.au> wrote in message news:42e4b0a1@clear.net.nz...
news:zeVrf.13954$m05.2843@clgrps12...

I take Celebrex for the arthritic inflamation in my knees and my
shoulders,, it works wonders for that kind of pain,, but it doesn't do
anything at all for my migraines. And I have to make sure I eat
something when I take it so as to not cause the old ulcer to act up,
so far so good.

Bear

PS: I was first prescribed Celebrex to see if it would give me any
relief at all from the migraine pain. No luck on that count, But with
it I was able to be far more mobile than I have been using any other
NSAIDs