Seems like .. anyone .. who acts like they know the ins and outs of
osteoarthritis .. is pulling your .. chain ..

BUT .. we are .. SURE .. blood spilled into the joint .. CAUSES ..
it ..

Of THAT we are .. **sure** .. http://tinyurl.com/2bmq65

-----------------------------------------------------------------
Am J Orthop (2004) 33: 5-9.

Understanding osteoarthritis of the knee--causes and effects.

RW Moskowitz, MA Kelly, DG Lewallen
Case Western Reserve University School of Medicine in Cleveland, Ohio,
USA. Osteoarthritis of the knee is common, increasing with age in both
women and men, but is generally more prevalent in women following the
fourth decade. Osteoarthritis may be primary/idiopathic or secondary
as a consequence of trauma, surgery, infection, or another disease
process. Normal articular cartilage is composed of an extracellular
matrix and chondrocytes. This matrix contains water, collagen fibers,
and proteoglycan macromolecules cross-linked into an integrated
network with hyaluronic acid. Osteoarthritis represents an imbalance
in the destructive and synthetic processes of the cartilage that leads
to erosion of the cartilage. In addition, there is a decreased
concentration and viscosity of the synovial fluid in osteoarthritic
patients, and this may decrease the lubricating and cushioning
properties of the joint. There is also an underlying inflammation of
the synovium, as well as damage or reactive changes in the subchondral
bone. The entire process is thought to involve a complex interaction
of cells and soluble mediators such as cytokines, growth factors,
inflammatory mediators, metalloproteinases, and chondrodegradative
enzymes. Understanding the biochemical and molecular changes that
occur in the joint is requisite to the development of treatments for
osteoarthritis of the knee that address both the symptoms of pain and
loss of mobility as well as the underlying disease progression. The
clinical goal of the management of osteoarthritis should be to treat
not only the symptoms of the disease, such as pain and decreased
mobility, but also the underlying pathology of the degenerative
process.

----------------------------------------------------------------------
Of course the FACT both arthritis and osteoarthritis RESEMBLE .. the
destruction .. the SAME destruction caused by blood spillage in the
joint in haemophilia .. is .. only .. coincidence.
And the FACT indocin , bucillamine and aspirin and sufasalazine .. are
iron BINDING drugs .. is again .. coincidence .. ?

-----------------------------------------------------------------------


<<snip>>
haemophilia-resembling diseases (Rheumatoid Arthritis and
Osteoarthritis)
<<snip>>

Haemophilia. 2005 Jul;11(4):308-18. Links
Assessing functional health status in adults with haemophilia: towards
a preliminary core set of clinimetric instruments based on a
literature search in Rheumatoid Arthritis and Osteoarthritis.
de Kleijn P, van Genderen FR, van Meeteren NL.
Van Creveldkliniek, University Medical Centre Utrecht, Utrecht, The
Netherlands. P.dekleijn@azu.nl

People with haemophilia experience a progressive deterioration of
their functional health status. Regular clinical assessment of
functional health status provides insight into their process of
disablement. As such, the development of a core-set of measurement
tools is warranted. The aim of this study was to gather data to
prepare a (preliminary) core set of clinically relevant and feasible
instruments to assess the functional health status of adults with
haemophilia, and to indicate their psychometric qualities. Therefore,
clinimetric instruments frequently used in two haemophilia-resembling
diseases (Rheumatoid Arthritis and Osteoarthritis) were reviewed from
the literature. An extensive search in Medline yielded 13 relevant
review articles, incorporating a total of 182 instruments, of which 40
were appropriate for haemophilia. Of these 40 instruments 3 measure
body structures, 13 body functions, 19 activities (of which 5 are
performance based and 14 self-report based), and 3 measure
participation. This classification is based on the International
Classification of Functioning, Disability and Health. Detailed
information regarding the psychometrics (reliability, validity and
responsiveness) of four instruments is described fully in the
literature, whereas the psychometrics of the majority of the other
instruments are only partly described. The results of this literature
study may contribute to the formation of a (preliminary) core set of
clinimetric instruments to assess the functional health status of
adults with haemophilia. Decisions on the final core set should be
held within the Musculoskeletal Committee of the World Federation of
Haemophilia.

PMID: 16011581 [PubMed - indexed for MEDLINE]

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Feb 11, 8:52 pm, numbnutz tom wrote:


WOW !!!! Listen to Mr. Know-it-all.

Picture of perfect mental idiocy.

Brainless jackass who won't answer questions.



Created with incisor and canine teeth to rip apart, chew, and eat
MEAT



.... Tom's incompetence knows no barriers of time or place.

You asked a question .. ?

I must have missed it ..

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

osteoarthritis .. is pulling your .. chain ..

BUT .. we are .. SURE .. blood spilled into the joint .. CAUSES ..
it ..

Of THAT we are .. **sure** .. http://tinyurl.com/2bmq65<<

This is another .. 'human model' .. OF .. osteoarthritis and
rheumatoid arthritis .. warfarin INDUCED / caused .. blood spillage
into .. joint ..

Radiation synovectomy for warfarin-induced haemarthroses --
Croot ...Hemarthrosis associated with sodium warfarin therapy.
Arthritis Rheum1976;19:98-102.[ISI][Medline]; Andes WA, Edmunds JO.
Hemarthroses and warfarin: joint ...
rheumatology.oxfordjournals.org/ cgi/content/full/39/5/570 - Similar
pages

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

<<snip>>
All of them exhibited erythrocyte extravasation
<<snip>>

Which means .. blood spillage ..
-----------------------------------------------------------------------------

Mechanisms of Tissue Injury with Reference to Rheumatoid Arthritis


Annals of the New York Academy of Sciences, Vol 256, Issue 1 39-64,
Copyright © 1975 by New York Academy of Sciences


--------------------------------------------------------------------------------

ARTICLES


Synovial membrane and fluid morphologic alterations in early
rheumatoid arthritis: microvascular injury and virus-like particles
H. R. Schumacher Jr


Eight patients have been studied during the first 6 weeks of
rheumatoid synovitis. All of them exhibited microvascular injury,
which was manifested by gaps between endothelial cells, vascular
occlusion, erythrocyte extravasation, or endothelial cell injury. In
four patients, a variety of virus-like particles were found associated
with the endothelium or perivascular cells. In two cases, particles
were seen in electron-dense deposits in vessel walls. Lymphocytes and
PMN infiltrated the synovial membranes, but plasma cells were
uncommon. Evidence of phagocytosis was prominent in synovial lining
cells and other large mononuclear cells, but not in PMN. These
observations are consistent with injury to synovium and, specifically,
synovial vessels as an early stage in RA synovitis. The virus-like
particles require further investigation, because nonviral cell
components remain very difficult to distinguish in electron microscopy
tissue sections.






ironjustice wrote:
Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Fire Chief <CALIFORNIA_CHIEF@PEOPLEPC.COM> wrote in message:
1171256429.205219.178250@m58g2000cwm.googlegroups. com,

Now there's some real irony.

So you can taunt him some more? Why don't you just leave him alone
instead?

Of course now you'll have to attack me for daring to question your
childish troll-poking. Then you'll try to justify your trolling by
claiming you have to do it to protect gullible newbies who might believe
Tom and stop taking their iron supplements. And you'll have to remind
everyone how he gets belligerent sometimes, while leaving out the fact
that he only does that in response to being poked relentlessly by
immature self-appointed netcops.

--
Juba
www.masterjuba.com