Oxidatively modified autoantigens in autoimmune diseases.
Kurien BT, Hensley K, Bachmann M, Scofield RH
Free Radic Biol Med. 2006 Aug 15; 41(4): 549-56

Free radical-mediated oxidative damage and consequent protein
modification by the end products of oxidative damage are important
mediators of cell toxicity and disease pathogenesis. Aldehydic
products, mainly the 4-hydroxy-2-alkenals, form adducts with proteins
and make them highly immunogenic. Oxidative modification of proteins
has been shown to elicit antibodies in a variety of diseases including
systemic lupus erythematosus (SLE), alcoholic liver disease, diabetes
mellitus (DM), and rheumatoid arthritis (RA). Oxidatively modified DNA
(8-oxodeoxyguanine) and low-density lipoproteins (LDL) occur in SLE, a
disease in which premature atherosclerosis is a serious problem. In
addition, immunization with 4-hydroxy-2-nonenal (HNE)-modified 60-kDa
Ro autoantigen elicits an accelerated epitope spreading in an animal
model of SLE. Advanced glycation end product (AGE) pentosidine and
AGE-modified IgG have been shown to correlate with RA disease activity.
Oxidatively modified glutamic acid decarboxylase is important in type 1
DM, while autoantibodies against oxidized LDL are prevalent in Behcet's
disease. The fragmentation of scleroderma-specific autoantigens occurs
as a result of oxidative modification and is thought to be responsible
for the production of autoantibodies through the release of cryptic
epitopes. In the face of overwhelming evidence for the involvement of
oxidative damage in autoimmunity the administration of antioxidants is
a viable untried alternative for preventing or ameliorating autoimmune
disease, although results in cardiovascular disease are disappointing.


Abstract · PubMed FullText · SFX · GS Clip Export InterDB ·
Terms Related · Graph Cites · Scopus · Tag · Review
10.1016/j.freeradbiomed.2006.05.020


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Numbnutz wrote:

HEY! STUPID!

oxidase A class of enzymes present in animal and plant
life that catalyzes an oxidation reaction; a respiratory
anzyme.

cytochromo oxidase An enzyme present in most cells
that oxidizes reduced cytochrome back to cytochrome.

oxidation [gr. oxys] 1. The process of a substance combining
with oxygen. 2. The loss of eletrons in an atom with an
accompanying increase in positive valence.

oxide ANY chemical compound in which oxygen is the
negative radical.

oxidoreductase An enzyme that catalyzes oxidation-reduction
reactions.

.... Tom reminds me of London --- always in a fog.

hey, chief. why are you bothering to explain it to him? do you really
believe that rusty rump even tries to understand what he posts? i think he
just wants everybody to believe he's soooo smart, for posting what, to him,
seems intelligent. doesn't matter to rusty rump if he understands it or
not. he just hopes nobody else understands it, so that they can't tell how
rusted his brain has become, adhering to the seat of his chair and all.
doncha think?

kate

"Fire Chief" <CALIFORNIA_CHIEF@PEOPLEPC.COM> wrote in message
news:1160200104.891484.242180@c28g2000cwb.googlegr oups.com...
Numbnutz wrote:

HEY! STUPID!

oxidase A class of enzymes present in animal and plant
life that catalyzes an oxidation reaction; a respiratory
anzyme.

cytochromo oxidase An enzyme present in most cells
that oxidizes reduced cytochrome back to cytochrome.

oxidation [gr. oxys] 1. The process of a substance combining
with oxygen. 2. The loss of eletrons in an atom with an
accompanying increase in positive valence.

oxide ANY chemical compound in which oxygen is the
negative radical.

oxidoreductase An enzyme that catalyzes oxidation-reduction
reactions.

.... Tom reminds me of London --- always in a fog.

Stay off my threads ..

You have nothing of .. value .. to add ..

All YOU need to understand .. is .. these researchers conclude ..
"antioxidants to BE .. used .."

<<snip>>
the administration of antioxidants is
a viable untried alternative for preventing or ameliorating autoimmune
disease
<<snip>>

Understand .. ?
Dig .. ?
Comprehendez ..?


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Well in your case .. I guess THAT .. tack .. works very well ..

You don't understand .. oxidative stress is .. rust .. ?

Let me explain .. it ..

Oxidative stress is .. rust ..

R-u-s-t / rust .. is .. oxidative stress ..

Oxidative stress is .. rust ..

R-u-s-t / rust .. is .. oxidative stress ..

Oxidative stress is .. rust ..

R-u-s-t / rust .. is .. oxidative stress ..

Oxidative stress is .. rust ..

R-u-s-t / rust .. is .. oxidative stress ..

R-u-s-t / rust .. is .. oxidative stress ..

Oxidative stress is .. rust ..

R-u-s-t / rust .. is .. oxidative stress ..

Oxidative stress is .. rust ..

R-u-s-t / rust .. is .. oxidative stress ..

Oxidative stress is .. rust ..

R-u-s-t / rust .. is .. oxidative stress ..

R-u-s-t / rust .. is .. oxidative stress ..

Oxidative stress is .. rust ..

R-u-s-t / rust .. is .. oxidative stress ..

Oxidative stress is .. rust ..

R-u-s-t / rust .. is .. oxidative stress ..

Oxidative stress is .. rust ..

R-u-s-t / rust .. is .. oxidative stress ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

<ironjustice@aol.com> wrote in message
news:1160219112.068886.110520@i42g2000cwa.googlegr oups.com...

Well in your case .. I guess THAT .. tack .. works very well ..


You don't understand .. oxidative stress is .. rust .. ?


********LOL! well, i'll be a green-toed, purple-earred, yellow-nosed,
platinum-skinned dweendizzle! i got it right!LOL btw, what part of rusty
rump didn't you understand?

Let me explain .. it ..Oxidative stress is .. rust ..R-u-s-t / rust .. is
... oxidative stress ..Oxidative stress is .. rust ..R-u-s-t / rust .. is ..
oxidative stress ..Oxidative stress is .. rust ..R-u-s-t / rust .. is ..
oxidative stress ..Oxidative stress is .. rust ..R-u-s-t / rust .. is ..
oxidative stress ..R-u-s-t / rust .. is .. oxidative stress ..Oxidative
stress is .. rust ..R-u-s-t / rust .. is .. oxidative stress ..Oxidative
stress is .. rust ..R-u-s-t / rust .. is .. oxidative stress ..Oxidative
stress is .. rust ..R-u-s-t / rust .. is .. oxidative stress ..R-u-s-t /
rust .. is .. oxidative stress ..Oxidative stress is .. rust ..R-u-s-t /
rust .. is .. oxidative stress ..Oxidative stress is .. rust ..R-u-s-t /
rust .. is .. oxidative stress ..Oxidative stress is .. rust ..R-u-s-t /
rust .. is .. oxidative stress ..

****w0w. you're waaay oxidatively stressed-out, aren't you---seems to have
triggered your OCD. i'd suggest you ask your doctor to increase your
therapeudic doses of rust-oleum. oh, and you might try applying some naval
jelly on that rusty rump of yours, too. hope that helps--afterall, this IS
a support group and we do try to be helpful. others will be along shortly,
to give you their helpful suggestions, too.

kate


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

to give you their helpful suggestions, too.<<

I tell you what ..

YOU .. say something about the .. article ..

You DON'T say .. fkall .. about ME ..

Maybe you and testosterone depleted .. 'chief' .. figure you can simply
forgo all rules of .. etiquette .. and attempt to .. PERSONALLY ..
attack someone .. but .. that IS .. against the .. **rules** ..
therefore EXPECT .. repercussions ..

Ya .. fkg .. dig ..?

<<snip>>
"It is better to wear out than to rust out;" don't expose your system
to more iron than it needs.
<<snip>>

http://www.highbeam.com/doc/1G1-19588769.html

Learn your sht .. or .. fo .. and in the MEANTIME .. S-T-F-U ..

Ya stupid fat .. cow ..

I think I called you that before .. ?

Didn't I .. ?

I didn't .. ?

Let me repeat it then ..

Ya stupid fat .. cow ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Shit. This is one sick group!

Please go away.

Absolutely brilliant!

Thank you

Bud wrote:
What is wrong with you?

Why are you all so hell-bent on hating anyone that has a genuine
interest in helping ourselves and others?

Am I in a group of people that are beyond help? Have I found hell?

LOL! It appears 'Exorcist' has the same email as 'Cab_Savvy'. Imagine
that. How could that happen? ROTFL

Hate? Try 'bored'. And it's hell to listen to you propounded 'helpers'
repeatedly trying to suck a buck from the newsgroup members just 'trying
to be helpful'. So please fuck off and leave us in peace, dimwit.

Exorcist (aka Cab_Savvy) just won't understand that these groups are for
support and not suck-a-buck activities. LOL!

"Bud" <bud@romance.org> wrote in message
news:A9CdnfrrG9HcarrYnZ2dnUVZ_oCdnZ2d@comcast.com. ..

that. How could that happen? ROTFL

how? while folding his laundry, he slipped his hands into his socks and
they spoke to him. unfortunately, he never lost his enthusiasm for show and
tell, bud.

kate

Kate wrote and asked:

It's like playing with bull in a ring before the final thrust.


Kindegarteners have a better understanding than he has.
After all, they have a higher IQ than his miserly single-digit
one.

.... Tom's a real big gun -- of small caliber and immense bore.

Exorcist wrote:
Exorcist/Cab_Savvy,

Which group from these cross-posted groups are you
posting in? You have to be a newbie (i.e. two nyms on the
same addy... duh...), ignorant of Tom's fanatical history,
or one of Tom's CLOSE relatives.

Otherwise, it boggles my mind to see you supporting
his lame habit.

Ginnie >^..^<

Numbnuts again displayed his single-digit IQ with:

oxidative stress The cellular damage caused by oxygen-derived free
radical formation. The 3 most important are superoxide (O2~), hydrogen
peroxide )H2O2), and hydroxyl ions. These are produced during normal
metabolic processes as well as in reaction to cell injury. SEE:
antioxidant; free radical; superoxide; superoxide dismutase.

superoxide A highly reactive form of oxybe. Superoxide is produced
during the normal catalytic function of certain enzymes, by the
oxidation of hemoglobin to methemoglobin, and when ionizing radiaiton
passes throuth water. It is also produced when granulocytes
phagocytize bacteria. Superoxide is destroyed by the enzyme superoxide
dismutase, which catalyzes the conversion of 2 molecules of superoxide
anion to 1 molecule of oxygen and 1 of gydrogen peroxide. Superoxides
play a part in many diseases and conditions, including central nervous
system damage in amyotrophic lateral sclerosis and endothelial damage
in hypertension and diabetes mellitus.

free radical A molecule containing an odd number of electrons.
These molecules contain an open bond or a half bond and are highly
reactive. The odd electron is represented in the chemical formula by a
dot. If two radicals react, both are eliminated. If a radical reacts
with a nonradical, another free radical is produced. This type of
event may become a chain rection.
The body has developed methods of defending against the harmful
effects of free radicals. Syoerixude dusnytasesm enzymes in
mitochondria, and antioxidants are effective in counteracting the
harmful effects of free radicals.


.... Numbnutz Tom is a closet homosapien.

hell? no - you have just found folks who are resistant to your sales
pitch - live with it.

Exorcist wrote:

Exorcist wrote:

No, but numbnutz Tom can lead you there.

He's well on his way already.


.... Tom gets lost in thought. It's unfamilar territory to him.