<<snip>>
We therefore advocate routine sampling of ferritin levels in patients
with unexplained joint complaints
<<snip>>

Neth J Med. 2006 Sep;64(8):307-9. Links
Sporadic porphyria cutanea tarda due to haemochromatosis.de Geus HR,
Dees A.
Department of Intensive Care, Erasmus Medical Centre, Rotterdam, the
Netherlands.


Haemochromatosis is a hereditary iron-overload syndrome caused by
increased intestinal iron absorption and characterised by
accumulation
of potentially toxic iron in the tissues. Sometimes this disease
presents as a cutanea porphyria. We describe a patient with joint
complaints and blistering skin lesions on sun-exposed skin. After
identifying the porphyria cutanea tarda by urine analysis we found
that


the serum activity of uroporphyrinogen decarboxylase (UROD) was
normal,


meaning a partial inactivation of UROD in liver tissue due to
external
factors. Further investigation showed the homozygous Cys282Tyr
missense


mutation and high levels of serum ferritin. It is important to
recognise the symptoms of iron overloading at an early stage because
hereditary haemochromatosis needs to be treated immediately. We
therefore advocate routine sampling of ferritin levels in patients
with


unexplained joint complaints.


PMID: 16990695 [PubMed - in process]


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numbnutz wrote:



iron overload: Organ failure that results from excessive accumulation of
iron in the body, usually as a result of frequent transfusions or
hemochromatois (see below).


hemochromatosis [hemo + chroma,color + osis,condition]

A ____genetic disease____ marked by excessive absorption and accumulation
of iron in the body. The disease is caused by one of several recessive
mutations that result in excessive absorption of iron from the GI tract. It
is not caused by secondary iron overload, as may occur in patients who have
received multiple transfusions or who have hemolytic anemia. The condition
is often diagnosed before it causes symptoms. SYN: bronze diabeties

DIAGNOSIS: Physical findings include gray or bronzed skin, enlarged liver,
arthritis, signs of congestive heart failure, and in males, testicular
atrophy. Lab studies to screen for the disease include the transferrin
saturation or ferritin tests. Liver biopsies from affected persons show
excessive stainable iron. Genetic testing is available to identify patients
with the most common forms of hemochromatosis.

TREATMENT: Treatment includes phlebotomy (blood drawing) done at regular
intervals until the patient's iron stores drop to below normal. Typically,
the ferritin level is monitored to ensure that this has occurred.

CAUTION: Blood removed from patients with iron overload cannot be used for
transfusion.

PATIENT CARE: The need for phlebotomy and its role in the removal of
excess iron are explained to the patient. To prevent dizziness or
hypotension, the patient is encouraged to drink plenty of fluids and to
abstain from vigorous exercise for the first 24 hours after the process.



Who went fishing and fed the multitudes with fish.


Created with molars and incisors to bite into and chew and enjoy M E A T
!!!!


.... It numbnuts tommy can't laugh at himself, we'll do it for him.

Hi Tom.

You seem to be an expert on the issue of iron and arthritis. I was
wondering why you are so interested in iron? Have you been studying
iron and its role in disease for a long time? As an arthritis
sufferer, I'm grateful that you have raised the issue.

If arthritis is caused or exacerbated by iron, can you tell me how
much iron is too much, and how can I tell if I have "too much"?

If iron is the, or one of, the culprits, regular blood transfusions
should cause a large reduction in arthritis symptoms. Is there a study
that shows this?

As an adult male, how much iron do I need in my supplements? How much
meat? Can cottage cheese stand in the place of meat?

I have had success is controlling my arthritis by following an
anti-inflammation regimen: 1) taking refined fish oil, 1tsp/day, 2)
reducing omega 6 oils, and, 3) cutting back on high glycemic load
foods such as refined flour products and potatoes. How would this
regimen fit with the iron overload theory?

Sincerely, BlackHawk

On 13 Apr 2007 20:13:53 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> wrote:

Any idea what those levels should be?

should cause a large reduction in arthritis symptoms. Is there a
study
that shows this?<<


You believe .. blood transfusions would HELP .. in somebody who has
too much iron in their .. body .. ?


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DEAD PEOPLE WALKING
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On 15 Apr 2007 08:48:57 -0700, "ironjustice" <teamtanner@hotmail.com>
wrote:

Hi Tom.

My apologies for having misled you with my question. I meant to say
"donations", not "transfusions".

Do you have any ideas on what might be the "ideal" ferritin level in a
mature male arthritis sufferer, which I can ask my doctor about?

Sincerely, BlackHawk

"Near-iron deficiency-induced remission of gouty arthritis"

http://rheumatology.oxfordjournals.o.../12/1550#BIB15

--------------------------------------------------------------------------------------------------------------
This article speaks to the use of low iron diet to induce further ..
it seems .. unreachable iron.
--------------------------------------------------------------------------------------------------------------

Hepatogastroenterology.
2005 Mar-Apr;52(62):563-6.

Additional effect of low iron diet on iron reduction therapy by
phlebotomy for chronic hepatitis C.

Kimura F, Hayashi H, Yano M, Yoshioka K, Matsumura T, Fukuda T,
Shigeto N, Yamahara S, Koushi F, Mishima Y, Yoshino T, Tanimoto M,
Kimura I.

Department of Internal Medicine, Tamano-Municipal Hospital, Tamano
City, Okayama, Japan.
f-kimura@po1.oninet.ne.jp

BACKGROUND/AIMS:
Iron-induced oxidative stress plays an important role in the
pathogenesis of chronic hepatitis C. Both phlebotomy for removing
body iron stores and low iron diet for minimizing portal iron supply
to the liver have been shown to improve serum transaminase levels in
patients with the disease. However, the cooperative effects of
phlebotomy and low iron diet have not yet been elucidated in detail.

METHODOLOGY:
A pilot study was undertaken to investigate whether a low iron diet
could improve the efficacy of phlebotomy in iron reduction therapy.
Of
21 patients diagnosed with chronic hepatitis C,
10 patients were treated with phlebotomy alone (group A) while
11 patients were treated with a low iron plus phlebotomy (group B).

Phlebotomy was repeated biweekly until serum ferritin levels reached
10 ng/mL in both A and B groups.

In addition, a low iron diet (iron intake of 8 mg/day or less) was
recommended for group B, followed by estimation of iron intake from
daily diet records.

RESULTS:
Serum alanine aminotransferase levels were significantly improved
from
106+/-30 to
68+/-22 IU/L (p<0.005, paired t-test) in group A and from

100+/-33 to
46+/-10 IU/L (p<0.002, paired t-test) in group B.

The enzyme levels after treatment were significantly higher in group A
(p<0.02, non-paired t-test), which showed a higher upward distribution
of the enzyme activity.

The estimated dietary iron intake in group B was reduced from
17.6+/-6.1 to
8.2+/-3.7 mg/day.

CONCLUSIONS:
These findings suggest that phlebotomy alone does not completely
remove iron-induced oxidative stress and a low iron diet induces an
additional
effect in iron reduction therapy for chronic hepatitis C.

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract



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Man Is A Herbivore!
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DEAD PEOPLE WALKING
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Thanks for your help, Tom. I really appreciate it.

That is very interesting information. It is a little off the mark for
me, though, as I do not have gout, or hepatitis, so far as I know.

I would really appreciate it if you can refer me to any studies which
address "reduction of (non-gouty) arthritis by reducing iron".

Sincerely, BlackHawk

On 15 Apr 2007 20:48:45 -0700, "ironjustice" <ironjustice@aol.com>
wrote:

On Apr 16, 8:48 am, "ironjustice" <ironjust...@aol.com> wrote:
Whether iron levels effect blood flow variations and supply to tissues?

tissues<<

You've spoken in the past .. as if .. you KNOW 'something' .. ABOUT ..
science and anatomy .. AND .. then you 'ask' .. the .. above .. ?

The above question has been answered .. MANY times .. and YOU ..
'somehow' .. missed it .. ?

Increased iron = erythrocytosis = hyperviscosity = decreased
perfusion ..

Yes .. it DOES affect the .. rheology .. OF .. the blood and supply of
blood / oxygen TO .. tissue ..


Who loves ya.
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Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On May 12, 8:32 pm, ironjustice <teamtan...@hotmail.com> wrote:
I also want to understand effect of circulating and stored iron on
blood flow and supply to tissues.

What .. part .. ?

Iron = increased red blood cell production .. ?

Iron = increased viscosity of the blood .. ?

Iron = increased rust / oxidation in the body .. ?

All of the above have 'trees' .. branching OUT .. from them .. with
EVERY disease involved ..

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

want to understand effect of circulating and stored iron on
I posted this before.
It is relatively newly recognized .. and therefore only JUST being
studied .. closely ..

Logic .. works ..

Low blood flow leads to venous stasis ..

Rheologics Announces Phase I Clinical Study on Blood Viscosity and
Peripheral Vascular Disease
EXTON, PA -- (MARKET WIRE) -- January 26, 2007 -- Rheologics, Inc., a
subsidiary of Rheologics Technologies, Inc. (PINKSHEETS: RTGI)
("Rheologics"), today announced the initiation of a Phase I study to
explore the effect of lowering blood viscosity in patients with
critical limb ischemia and end-stage peripheral vascular disease. The
study is taking place at the Seoul Veterans Hospital in Seoul, South
Korea utilizing the Rheolog® blood viscometer.


Peripheral vascular disease, or peripheral arterial disease ("PAD"),
is a form of atherosclerosis that occurs in the lower extremities and
affects 1 in 20 people over the age of 50, between 8 to 12 million
people in the United States. There are approximately 63 million
patients affected by PAD in developed countries worldwide.
Approximately 31 million of the affected population are symptomatic
and about 7.5 million of those require treatment. PAD is the cause of
over 100,000 lower extremity amputations in the U.S. every year.


The Phase I study will include patients divided into 2 groups on the
basis of a randomized controlled trial: patients in the control group
receiving conventional treatment and patients receiving treatment to
lower blood viscosity. The objective is to evaluate the effect of
blood viscosity reduction in end-stage PAD resistant to maximal
medical therapy and where revascularization therapy (both
percutaneous
and surgical) has either proved insufficient or is contra-indicated
or
declined by the patient, usually resulting in amputation. The primary
outcome parameters will be the salvage rate of the limb as compared
with the salvage rate of the limb with conventional therapy.


Kenneth R. Kensey, MD, Chief Scientific Officer of Rheologics, said,
"Whole blood viscosity is the parameter that best quantifies the
injurious characteristics of blood flow. Since the blood pressure in
the legs is typically three times greater than the blood pressure in
the arms due to the pulling force of gravity, we have good reason to
believe that blood flow, especially highly viscous and injurious
blood
flow, is the true culprit behind PAD. Leg amputation because of PAD
is
devastating for each and every patient. If by lowering blood
viscosity, we can improve the limb salvage rate of end-stage PAD
patients, we will have made a major contribution to the quality of
millions of lives around the world."


The Rheolog® is an FDA IDE-exempt device approved for research and
for
providing additional information in the interpretation of disease.


About Rheologics Technologies, Inc.


Rheologics is committed to developing and commercializing innovative
medical technologies that improve the diagnosis and treatment of
human
disease. The Company is accomplishing its mission by monitoring an
overlooked basic physiological parameter -- whole blood viscosity.
Rheologics believes that its innovations will ultimately enable the
preventative diagnosis of diseases and the development of new cost-
effective therapies that conquer today's most difficult medical
problems, thereby improving the quality of life for millions of
people
worldwide. Further information on Rheologics may be found at
www.rheologics.com.


Cautionary Note Regarding Forward-Looking Statements


This press release contains certain forward-looking statements within
the meaning of Section 27A of the Securities Act of 1933 and Section
21E of the Securities Exchange Act of 1934, including but not limited
to statements regarding the Company's beliefs and expectations about
the performance and benefits of its technology; marketing and
commercialization activities; and our beliefs regarding research and
development efforts. These forward-looking statements involve certain
risks and uncertainties that could cause actual results to differ.
All
forward-looking statements herein are based on information available
to us as of the date hereof, and we undertake no obligation to update
forward-looking statements to reflect events or circumstances
occurring after this date.


-----------------------------------------------------------------------
---------


Contact:
Contact Rheologics:
Daniel Cho
800-969-2585
Email Contact


or


Investor Relations
Jody Janson
ISD, Inc.
585-232-5440
Email Contact
http://www.istockdaily.com


SOURCE: Rheologics Technologies, Inc.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
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DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On May 13, 5:24 am, ironjustice <teamtan...@hotmail.com> wrote:
Thanks. We may have understand possible blood flow varaitions as a
action of iron and free iron more deeply as iron serve as oxidant and
as a nutrient. Its can also serve as a nutrient to microbial and
neoplamic cells so body's mechansm may either encourage its exposure
for oxidant and nutrient pupose to our healthy cells OR may discourage
its exposure to pathogenic and cancer creatures to starve them. If
such actions of more or less iron exposre is possible by variations in
blood flow or not, is need to be understood. Btw, whether iron is a
vasoconstrictor or vasodilator?

Furthur calcium may also related/resemble to iron related disorders,
so iron and calcium and their inter-relationship is be better
understood. Can you tell about iron-calcium interreationship?