Toxicol Pathol. 2005;33(5):533-9. Related Articles, Links


Ultrastructural and morphometrical evaluation of the parathyroid gland
in iron-lactate-overloaded rats.

Matsushima S, Tsuchiya N, Fujisawa-Imura K, Fujisawa-Imura K, Hoshimoto
M, Takasu N, Torii M, Ozaki K, Narana I, Kotani T.

Pathology Section, Drug Safety Evaluation, Developmental Research
Laboratories, Shionogi & Co., Ltd, Toyonaka, Osaka, 561-0825, Japan.

Iron lactate was given to Sprague-Dawley rats intravenously at the
dosage of 10 mg/kg/day and the early effects on the parathyroid gland
were examined ultrastructurally along with the blood level of
parathyroid hormone (PTH) after single, 3-day or 6-day administration.
Blood levels of electrolytes and other parameters related to osteoclast
dynamics were also measured by blood chemistry and histopathology. The
plasma parathyroid hormone (PTH) level was elevated in the single and
3-day dosing group but was reduced in the 6-day dosing group.
Histopathologically, an increase of osteoclasts in the primary
spongiosa was observed in the 3- and 6-day dosing groups. Image
analysis of the parathyroid gland revealed that the average area of the
storage granule decreased during a experimental period, with the number
of storage granules decreasing in the 3- and 6-day dosing group. The
chief cells of the parathyroid gland were moderately atrophied in the
6-day dosing group. These results demonstrate that iron lactate
immediately promotes discharge of PTH from the storage granules after
the treatment and induces an increase of osteoclasts in the primary
spongiosa. The findings collectively suggest a pathophysiological
mechanism of iron lactate-induced osteopenia in rats.

PMID: 16048848 [PubMed - in process]

--------------------------------------------------------------------------------

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Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
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Sorry bonehead, no iron overloaded rats here. Please drive through. Or
you could entertain us with your Captain Kirk impressions some more. Up
to you.

Cheers!

--
spammage trappage: replace fishies_ with yahoo

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/

I wonder why an iron binder like lactoferrin would promote bone ..
growth ..

Clin Med Res. 2005 May;3(2):93-101. Related Articles, Links


Lactoferrin - a novel bone growth factor.

Naot D, Grey A, Reid IR, Cornish J.

Department of Medicine, University of Auckland, Private Bag 92019,
Auckland, New Zealand. . d.naot@auckland.ac.nz.

Lactoferrin is an iron-binding glycoprotein that belongs to the
transferrin family. It is present in breast milk, in epithelial
secretions, and in the secondary granules of neutrophils. In healthy
subjects lactoferrin circulates at concentrations of 2-7 x 10(-6) g/ml.
Lactoferrin is a pleiotropic factor with potent antimicrobial and
immunomodulatory activities. Recently, we have shown that lactoferrin
can also promote bone growth. At physiological concentrations,
lactoferrin potently stimulates the proliferation and differentiation
of primary osteoblasts and also acts as a survival factor inhibiting
apoptosis induced by serum withdrawal. Lactoferrin also affects
osteoclast formation and, in murine bone marrow culture, lactoferrin
potently inhibits osteoclastogenesis. In vivo, local injection of
lactoferrin above the hemicalvaria of adult mice results in substantial
increases in the dynamic histomorphometric indices of bone formation
and bone area. The mitogenic effect of lactoferrin in osteoblast-like
cells is mediated mainly through LRP1, a member of the family of
low-density lipoprotein receptor-related proteins that are primarily
known as endocytic receptors. Using confocal laser scanning microscopy,
we demonstrated that fluorescently labeled lactoferrin is endocytosed
and can be visualized in the cytoplasm of primary osteoblastic cells.
Lactoferrin also induces activation of p42/44 MAPK signaling in primary
osteoblasts, but the two pathways seem to operate independently as
activation of MAPK signaling, but not endocytosis, is necessary for the
mitogenic effect of lactoferrin. We conclude that lactoferrin may have
a physiological role in bone growth and healing, and a potential
therapeutic role as an anabolic factor in osteoporosis.

PMID: 16012127 [PubMed - in process]

--------------------------------------------------------------------------------

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

ironjustice@aol.com wrote:
Absolutely nothing to do with its iron binding properties:
"At physiological concentrations,
lactoferrin potently stimulates the proliferation and differentiation
of primary osteoblasts and also acts as a survival factor inhibiting
apoptosis induced by serum withdrawal"

But you'd know this if you had more than a year 10 education. Now it's
time to start with the Captain Kirk impressions. C'mon, you know you
want to!

Cheers!


--
spammage trappage: replace fishies_ with yahoo

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/

lactoferrin potently stimulates the proliferation and differentiation
of primary osteoblasts and also acts as a survival factor inhibiting
apoptosis induced by serum withdrawal"

But you'd know this if you had more than a year 10 education. Now it's
time to start with the Captain Kirk impressions. C'mon, you know you
want to!
<<

Yep .. nothing to do with its' iron binding properties ..

If using iron binders like lactoferrin stimulate bone growth .. and
using iron reducing .. induces bone growth ..

Then .. iron .. targeting .. induces .. bone .. growth ..

YOU .. are stupid ..

How IS your melting skeleton .. there .. spondy ...

STILL getting the iron removed .. ?

Quit .. that ..

It .. is .. waste of time ....

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

ironjustice@aol.com wrote:
4

6

16

(btw- it's not iron targetting, it's a completely different mechanism:
if you had more than a year 10 education you'd have better english
comprehension)

7

(you used an odd number of full stops, you're slipping!)

2

4

8


--
spammage trappage: replace fishies_ with yahoo

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/

You have something to say .. about lactoferrin .. ?

Lactoferrin .. ISN'T .. an iron binder .. ?

Lactoferrin IS .. an iron binder ..

It is the bodies' FIRST LINE .. iron .. binder ..

You saying it .. isn't .. an .. iron binder .. just proves you are very
... STUPID ..

How DOES that .. feel ..

To BE ... stupid ..

Must be a btch to be .. stupid .. ..

Eh ..

Does it .. hurt .. alot .. ?

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

ironjustice@aol.com wrote:
Is that you asking, or Captain Kirk?

Like I said, you don't what you're cutting and pasting. If you'd
actually read the article you'd be able to answer those questions.

Are you sure? You were'n't even sure if it was an iron binder a moment ago.

There's your lack of english comprehension again. Go back and read what
I typed and try again!

Enlighten me :-)

Well, you'd know!

You should make your boyfriend use some lube then.


--
spammage trappage: replace fishies_ with yahoo

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/

Won't be too long before they are treating you in some type of hospice
...

Probably the same type of hospice they use for those who go .. nuts ..
from too much iron ..

You have too much .. iron .. ?

Yes I believe you do .. ?

Is that WHY you are being .. iron .. reduced .. ?

Too much .. iron .. ?

Yep ..

Are you going .. nuts .. ?

Heh .. heh ..

Enjoy .. it ..

Heh .. heh ..

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

ironjustice@aol.com wrote:
Why are you so obsessed with my nuts? Have you made sure to update your
local authorities re: your status as an S.O.?

I don't think I'm comfortable with you enjoying yourself while
fantasizing about my nuts.