<<snip>>
iron-catalysed formation of destructive oxygen metabolites
<<snip>>
Haemophilia. 2006 Jul;12 Suppl 3:117-21. Related Articles, Links
Pathogenesis of haemophilic arthropathy.
Roosendaal G, Lafeber FP.
University Medical Center Utrecht, Utrecht, The Netherlands.
Summary. The pathogenetic mechanism of haemophilic arthropathy is
multifactorial and includes degenerative cartilage-mediated and
inflammatory synovium-mediated components. Intra-articular blood first
has a direct effect on cartilage, as a result of the iron-catalysed
formation of destructive oxygen metabolites (resulting in chondrocyte
apoptosis), and subsequently affects the synovium, in addition to
haemosiderin-induced synovial triggering. Both processes occur in
parallel, and while they influence each other they probably do not
depend on each other. This concept resembles degenerative joint damage
as found in osteoarthritis as well as inflammatory processes in
rheumatoid arthritis. These processes finally result in a fibrotic and
destroyed joint.
PMID: 16684006 [PubMed - in process]
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