Topically applied lecithin .. ?

MMP-1 is inhibited by lecithin / phytic acid ..

J Autoimmun 2002 Nov;19(3):161-8

These results indicated that the over-expression of MMP-1 in RA SF
might be
related to the activation of DDR2, and collagen II, act as DDR2
ligand, might
be one of the stimulators of the over-expression of MMP-1 of RA SF.


PMID: 12419287, UI: 22307318


--------------------------------------------------------------------------
------


This article specifically states .. MMP-1 is TOTALLY ABOLISHED by
phytic acid.


<<snip>>
Phytic acid, a naturally occurring compound present in food, is an
anti-angiogenic compound because it inhibits the activation of pro-
MMP-1 and
the activity of MMP-1.
<<snip>>


23
Interaction of metalloproteinase-1 (MMP-1) with phytic acid:
Antiangiogenic
activity of phytic acid
R. R. BANSODE and J. N. Losso. Food Science, Louisiana State
University, 111
Food Science Building, Louisiana State University, Baton Rouge, LA
70803


There is strong evidence that metalloproteinases (MMPs) participate
in
cardiovascular diseases, angiogenesis, tumor growth, and metastasis.
Gelatinase
I (MMP-1), is secreted as an inactive proenzyme (pro-MMP-1) and must
be
activated before it can act as a catalyst of collagen degradation.
Activators
of pro-MMP-1 include serine proteinases and prooxidants. In most
chronic
diseases, such as cancer, arthritis, inflammation, and diabetes, the
concentration of endogenous inhibitors is often low to counteract the
action of
over expressed proteinases. Inhibitors of MMPs are thus attractive
targets for
degenerative disease prevention and possibly treatment. Phytic acid
(myo-inositol hexaphosphate) is naturally occurring in dicotyledonous
and
monocotyledonous seeds. Although an inverse relationship between
phytic acid
concentration in the diet and cancer rate has been demonstrated, the
mechanism
by which phytic acid may reduce cancer has not been fully explained.


The objective of this research was to determine the ability and
minimum
concentration of phytic acid to inactivate the activation of pro-MMP1
in an
effort to delay the onset and progression of basement degradation and
the
progression of angiogenesis.


The inhibition of pro-MMP-1 activation by phytic acid was investigated
using
biotinylated gelatin, gelatin zymography, electrophoresis with silver
staining,
and fluorescence quenched substrate hydrolysis. Phytic acid at
concentration of
40 nM completely inhibited trypsin activation of pro-MMP-1.
Quantitation of
gelatinolytic activity of phytic acid -treated trypsin-activated pro-
MMP-1
demonstrated the absence of gelatin degradation. Silver staining
showed the
pattern of BBI inactivation of pro-MMP-1 activation with increased
concentration of phytic. Lower rate of substrate hydrolysis following
quenched
fluorescence substrate hydrolysis was inversely proportional to the
concentration of phytic acid present in the reaction medium.


Phytic acid, a naturally occurring compound present in food, is an
anti-angiogenic compound because it inhibits the activation of pro-
MMP-1 and
the activity of MMP-1.


Session 6, Biotechnology
8:30 AM - 12:00 PM, 2002-06-18
-------------------------------------------------------

There was a question as to whether topically applied lecithin would
be
efficacious ..

The article shows it .. is ..

This article ALSO shows it / oil crosses the skin / epidermis.

http://www.indianpediatrics.net/oct2...t-998-1005.htm

Indian Pediatrics 2005; 42:998-1005

Transcutaneous Absorption of Topically Massaged Oil in Neonates


Kirti Solanki, Manoj Matnani, +Mrudula Kale, +Kalpana Joshi, Ashish
Bavdekar, Sheila Bhave and Anand Pandit




and +School of Health Sciences, University of Pune, Pune 411 007,
India.

Address for Correspondence : Dr. Sheila Bhave, Department of
Pediatrics, KEM Hospital, Pune 411 011, India. E-mail:
kem...@vsnl.com


Abstract


Objective:
To study the transcutaneous absorption of traditionally
massaged oil in newborns and to specifically compare the effects of
(i)
essential fatty acid (EFA) rich - safflower oil and (ii) saturated
fat
rich coconut oil, on fatty acid profiles of massaged babies. Design:
A
short term randomised controlled study.
Setting:
Tertiary care NICU of a large teaching hospital and a research
laboratory
of a University complex.
Methods:
120 study babies were randomly assigned to three oil
groups (i) safflower oil (n = 40) (ii) coconut oil (n = 40) and (iii)
no oil controls (n = 40). In each group, babies were selected in
three
subsets as per their gestational ages viz., (a) <34weeks, (b) 34-37
weeks, (c) > 37 weeks. 5 mL of the designated oil was massaged four
times a day (6hrly) for five days under controlled conditions of
temperature and feeding. Pre and post oil massage samples of blood
were
analysed for triglycerides and fatty acid profiles using gas
chromatography.
Results:
Post oil triglyceride values were significantly raised in both the oil
groups
and also in controls.
However, the quantum of rise was significantly higher in oil groups
as
compared to controls (p <0.05). Fatty acid profiles (gas
chromatography) showed significant rise in EFAs (linolenic acid and
arachidonic acid) in safflower oil group and saturated fats in
coconut
oil group (p <0.05). Changes were more evident in term babies. There
were no side effects associated with the massage.
Conclusion:
This study shows that topically applied oil can be absorbed in
neonates and
is probably available for nutritional purposes. The fatty acid
constituents of the oil can influence the changes in the fatty acid
profiles of the massaged babies.


Key words: Fatty acid profile, Topical absorption, Traditional oil .

-----------------------------------------------------------------------

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

<snip rant>

On Fri, 06 Jul 2007 13:45:43 -0700, ironjustice wrote:

God I hate it when I reinstall and forget to backup my killfile.

"Simon Scott" <scotty_nospam@amnet.net.au> wrote in message
news:1184063121.538921@angel.amnet.net.au...
I also forgot to backup my killfile

Hi,
I don't understand what you are telling us...I have an Autoimmune disease,
but they don't know which one yet..I'm on prednisone and MTX...Trying to get
of the prednisone but takes a long time..I'm on 9mgs now.
My problem is my legs are weak, can't walk to far at one time, can't climbs
stairs and hear to get up after I've sat down. I've always been so active
it's driving me crazy...
If you know what you think it can be let me know?
Thanks so much......Nel
Do you have one of the diseases..
"ironjustice" <teamtanner@hotmail.com> wrote in message
news:1183754743.904875.148470@m37g2000prh.googlegr oups.com...

Nel wrote:

Neither does he. NUMBNUTZ tommy, aka rustbucket, aka ironjustice, only
cuts and pastes whatever he can find on the internet that appeals to him.

I certainly hope that the doctor(s) - rheumatologist(s) - can give a better
diagnosis very, very soon.

There are more than 100 types/forms of arthritis/autoimmune diseases, and
the sooner everyone - including yourself - know exactly what you have the
sooner the proper treatment can begin.


.... Epitaph: F. LEE BAILEY-- Case Closed

"Nel" <yanelgal@prodigy.net> wrote in message
news:FjpCi.1601$3Y1.1298@newssvr17.news.prodigy.ne t...

Hi Nel,,,, Methx is taken once a week or sometimes twice in the same day
but once a week. A person has to take enough on that day to slow your
immune system down. There are two ways two take Methx shots and pills and
the pills are 2.5 mg. I took 17.5 mg once a week for lots of years and the
shots of Methx for only a year. The thing is,,,, I had to get up to 15 mg
before it even started to help me with my RA. Having said all that it
leads up to asking,,,,, how much Methx do you take a week??? Have you been
taking a blood test once a month to see how your liver is reacting to the
medicine? Do you take folic acid?
Harv

Thank you so much for all your answers everyone..

I've had a ct scan, 2 pet scans, mri, emg, nerve conduction test, lung
ex-ray and everything was OK. I even had a bone density test, and that was
fine, good bones..My Rheumy has them draw a barrel of blood every four
weeks. I guess the only thing that's left is a muscle biopsy, but it could
be a false negative if I"m on prednisone, so I just have to wait..Can't
believe I would ever get anything like this, I have my treadmill, stationary
bike, danced 2 times a week, weights, and yoga. Never hear of this
before..Now there's a group for all the Myositis people. (autoimmune)
Harvey, I take my MTX once a week. I'm up to 8 on Weds. now. I didn't know
how it worked, thanks.
I also take folic acid everyday except the day I take the mtx. I see him
Tues. and he will maybe take me down one mg on the prednisone(I hope, has to
be slow) and add one to the mtx..The pred. is awful. My hair is thinning, my
face is fat(getting a bit better)and I'm so bruised up, my hands and lower
legs. I'm also getting a stomach..UGH!!!

Anything else you can tell me is very helpful. I"I'm getting worried, as
one of the girls in the group that had PM, and DM died last week..I think it
must had got her in the lungs too. That seems to happen to lots of the
people in the group.
Can you tell me what your DX was, and symptoms?
Thanks to everyone...
I'll ignore that guy next time.;=)...Nel
"

"Nel" <yanelgal@prodigy.net> wrote in message
news:9KGCi.5271$z_5.4935@nlpi069.nbdc.sbc.com...
That would be 20mg a week and that is enough to have an effect on your
immune system. Your RD may add another pill or add another DMARD like
Arava if the doc still sees on going damage.

I also take folic acid everyday except the day I take the mtx. I see him
That is the methx and you might add grapeseed extract or more folic to stop
the hair loss.

my
Prednisone keeps you hungry and a person really has to control what and how
much a person eats. It is something we all have to do. The prednisone
also makes my skin thin and it tears easily.

Please keep in mind that everything we take for what we have,,,, has side
effects and that you can put them all together and they are not as bad as
uncontrolled RA lets say. Eyes, ears, voice box, and the most important
our veins and arteries are under attack and that is what we die of early.
If a person has Lupus it is their organs that come under attack early.
If your RD can find a balance of medicine to control what you have,,,,
you can do quite well. I use myself as an example but I have been taking
DMARDs for almost 30 years and can do most things and can go and do as I
please as long as I take my medicine with me. I do not want my words to
make you down hearted but I say them in hopes you will accept what you have
and learn to make the best of it and the best of it can be a good life.

Harv

Hi,
I don't understand what you are telling us...I have an Autoimmune
disease,
but they don't know which one yet.. If you know what you think it
can be let me know? <<

The iron from the meat you eat accumulates / builds higher and higher
in the body and overwhelms the bodies ability to keep it from causing
your disease BY iron **poisoning**.

"Plant irons are most beneficial to the body because their absorption
remains
safely regulated, whereas iron from animal sources tends to accumulate
to
levels which increase free radical activity contributing to heart
disease,
cancer, and the aging process.
--Presented at the National Meeting of the American Chemical Society
by
Tung-Ching Lee, a food scientist at Rutgers University in New
Brunswick, N.J.,
April 2000. reprinted from Good Medicine, PCRM, August 2000 "
------------------------------------------
The links below give a rundown of the problems of excess iron.
------------------------------------------
"This excess Iron is the root cause of Inflammatory and Autoimmune
disorders.
This excess Iron gets deposited in brain and other organs such as
liver, kidneys etc. causing variety of diseases ranging from
recurring
infections to cancer "

http://tinyurl.com/2cefle


Authored By: Dr Rev LD Wedewer, PhD


Research Additions: Kathy Blanco


11/29/2002

------------------------------------------

"I believe that Autistic individuals have an inborn error in Iron
metabolism. Human body does not have any mechanism to excrete Iron.
Iron is lost mostly through growth of hair, skin, sweat and bleeding.
"

http://www.autismhelpforyou.com/Prenatal%20Vitamins.htm
------------------------------------------

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk