- Aspirin Risks In Healthy Individuals
- Posted by Roman Bystrianyk
http://www.healthsentinel.com/org_ne...ist_item&id=16
Roman Bystrianyk, "Aspirin Risks In Healthy Individuals", Health
Sentinel, January 16, 2005,
Felix Hoffman at Bayer Industries synthesized aspirin over 100 years
ago. Today there have been many ads promoting aspirin's potential to
reduce the risk of heart attack and stroke in certain people. However,
the decision to use aspirin as a preventative is not as simple as it
looks. What generally has not been analyzed are the risks and costs
associated with aspirin therapy.
In the January issue of The Annals of Pharmacotherapy the authors
analyze the lifetime cumulative risk, the potential negative effects on
quality-adjusted-life-years (QALYs), life expectancy, and cost of
aspirin therapy. The authors construct a model of healthy individuals
starting at age 50 taking a 325 mg enteric-coated daily aspirin. Based
on numerous references the authors take into account adverse effects
such as upper gastrointestinal bleeding, quality of life factor, and
aspirin cost.
Based on their analysis, aspirin therapy only had a modest negative
effect on both QALYs and life expectancy. The average lifetime cost was
determined to be $460 per person.
However, the authors found that, "for every 15 healthy 50-year-old
men started on aspirin therapy, one will have a complication in his
lifetime; for every 556 individuals started on aspirin therapy, one
will die from complications." Comparison of death risk of lifetime
aspirin therapy (1 in 556) versus other mortality risks were listed as
follows: hip surgery (1 in 345), cardiac catheterization (1 in 500),
general anesthesia (1 in 3,685), annual accidents (1 in 3,014), food
poisoning (1 in 56,424), sky diving (1 in 70,130 per dive), and yearly
driving with a cell phone (1 in 76,900).
The authors also note that, "starting aspirin at an earlier age
resulted in a larger absolute reduction in both QALYs and life
expectancy, increased cost, and not surprisingly, a greater number of
complications."
The authors also analyzed the use of proton pump inhibitors (PPIs) to
reduce the aspirin risk. They determined a modest increase in quality
of life and life expectancy, but at a substantial increase in cost. The
addition of PPIs resulted in an increase from an average lifetime cost
of $460 per person to $18,400.
The authors do not attempt to incorporate all the potential benefits of
aspirin, as the aim of the study was to determine the risk. The authors
also note that, "although good published data exist to accurately
model the drawbacks of aspirin therapy, the benefits of aspirin in
cancer chemoprevention are preliminary at best and will likely not be
apparent for at least 10 years of aspirin therapy. Short-term data for
the efficacy of aspirin for the prevention of primary coronary events
exist, but long-term data are currently unavailable."
SOURCE: The Annals of Pharmacotherapy, January 2005
- Posted by GaryG
"Roman Bystrianyk" <rbystrianyk@gmail.com> wrote in message
news:1105902870.848363.318300@z14g2000cwz.googlegr oups.com...
I wonder why they studied "full strength" aspirin (325 mg). Most
recommendations I've seen are for "baby" aspirin (81 mg).
GG
- Posted by bj
"GaryG" <sorrynoemail@NOSPAMX.com> wrote in message
news:1wzGd.15327$IF3.3665@fe05.lga...
Perhaps they were looking for adverse results (i.e. they knew the conclusion
they *wanted* to reach), so did what they could to stack the deck.
bj
- Posted by Roman Bystrianyk
Aspirin dosing is controversial, with various studies or editorials
confirming, recommending, or reporting that aspirin doses from 30 to
1400 mg/d are effective for specific clinical conditions. Most studies
and consensus panels, however, recommend aspirin dosages between 81 and
325 mg/d.
- Posted by madiba
bj <bjones44@bellatlantic.net> wrote:
No, for keeping stents, PTAs and arteries in general 'clean' the 81mg is
theoretically sufficient (every second day in fact) assuming you are the
standard 70kg male. For the supposed cancer prophylaxis higher doses
(100-400mg/day) are recommended by various authors.
madiba
- Posted by Bill
"Roman Bystrianyk" <rbystrianyk@gmail.com> wrote in message
news:1105902870.848363.318300@z14g2000cwz.googlegr oups.com...
Thanks for posting this. I find it a little difficult to interpret, however.
They say they did not attempt to include all the benefits of aspirin. So what
did they include? And is it possible that what they excluded would overwhelm
the risks?
Also, on PPI they do not say how much complications were reduced. It is
possible that the reduction in complications would compensate for the
increased cost.
Bill
- Posted by Roman Bystrianyk
The final paragraphs were modified in hopes that it makes the
information more clear. Have a good day.
The authors also analyzed the use of proton pump inhibitors (PPIs) to
reduce the aspirin risk. They determined a modest increase in quality
of life and life expectancy, and a decreased risk in major and
intermediate GI (gastrointestinal) bleeds by 50%, but at a substantial
increase in cost. The addition of PPIs resulted in an increase from an
average lifetime cost of $460 per person to $18,400.
The authors do not attempt to incorporate any of the potential benefits
of aspirin. On the contrary, as the aim of the study was to determine
the risk, all complication rates attributable to aspirin from numerous
scientific sources were utilized. The authors note that, "although
good published data exist to accurately model the drawbacks of aspirin
therapy, the benefits of aspirin in cancer chemoprevention are
preliminary at best and will likely not be apparent for at least 10
years of aspirin therapy. Short-term data for the efficacy of aspirin
for the prevention of primary coronary events exist, but long-term data
are currently unavailable."
- Posted by menu boy
"Roman Bystrianyk" <rbystrianyk@gmail.com> wrote in message
news:1105902870.848363.318300@z14g2000cwz.googlegr oups.com...
This is a higher dose than recommended. I think it's like 80 mgs.
- Posted by menu boy
"bj" <bjones44@bellatlantic.net> wrote in message news:s_zGd.5919$c%6.4079@trnddc03...
- Posted by menu boy
"madiba" <down@thekraal.com> wrote in message news:1gqi69k.rn0zvjypzf7kN%down@thekraal.com...
Source?
- Posted by alankar gupta
Aspirin for cancer prophylaxis? Did I miss something? Could you please give
a source for your comments.
PPI to reduce complications of aspirin: interesting. PPI can have very bad
effects on GI due to low gastric acidity (it blocks proton pump in gastric
parietal cells, and thus cause low secretion of H+ ions).
I am to very hesitant and worried to even think about prescribing lifelong
prophylactic PPI to any patient. PPI is prescribed only for duodenal ulcer,
Zollinger-Ellison syndrome and resistant ulcer patients and it has high risk
of side effects.
Al
"madiba" <down@thekraal.com> wrote in message
news:1gqi69k.rn0zvjypzf7kN%down@thekraal.com...
- Posted by awthrawthr@yahoo.com
It was reported recently that an aspirin a day INCREASES the chances of
macular degeneration by 44%.
Macular degeneration is perhaps the most common cause of blindness in
the elderly.
And what does aspirin do? It turns off your platlet cells when you have
arterial bleeding from extra-low-density cholesterol robbing an oxygen
molecule from your arterial wall. So now you have two problems instead
of one: bleeding and defective platelets cells.
Bromelain is a better option. It dissolves sticky fibrin, which is the
sticky substance responsible for arteries getting the ten-car-pile-up
effect that narrows arteries. Bromelain also dissolves blood clots.
- Posted by me
"alankar gupta" <guptaa@pediatrics.ohio-state.edu> wrote in message
news:csf496$gus$1@charm.magnus.acs.ohio-state.edu...
Lots of sound evidence:
http://tinyurl.com/5g43t
- Posted by Bill
<awthrawthr@yahoo.com> wrote in message
news:1105931183.487573.310880@z14g2000cwz.googlegr oups.com...
"It was reported recently" is not a good referrence. Which is not to say this
is incorrect. Only that it would be helpful to know if the source is reliable.
Bill
- Posted by Andrew B. Chung, MD/PhD
Bill wrote:
Aspirin is *not* associated with age-related neovascular macular
degeneration:
http://makeashorterlink.com/?O2E72204A
At His service,
Andrew
--
Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
**
Suggested Reading:
(1) http://makeashorterlink.com/?L26062048
(2) http://makeashorterlink.com/?O2F325D1A
(3) http://makeashorterlink.com/?X1C62661A
(4) http://makeashorterlink.com/?U1E13130A
(5) http://makeashorterlink.com/?K6F72510A
(6) http://makeashorterlink.com/?I24E5151A
(7) http://makeashorterlink.com/?I22222129
- Posted by Andrew B. Chung, MD/PhD
Bill wrote:
Aspirin is *not* associated with age-related neovascular macular
degeneration:
http://makeashorterlink.com/?O2E72204A
At His service,
Andrew
--
Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
**
Suggested Reading:
(1) http://makeashorterlink.com/?L26062048
(2) http://makeashorterlink.com/?O2F325D1A
(3) http://makeashorterlink.com/?X1C62661A
(4) http://makeashorterlink.com/?U1E13130A
(5) http://makeashorterlink.com/?K6F72510A
(6) http://makeashorterlink.com/?I24E5151A
(7) http://makeashorterlink.com/?I22222129
- Posted by Andrew B. Chung, MD/PhD
Bill wrote:
Aspirin is *not* associated with age-related neovascular macular
degeneration:
http://makeashorterlink.com/?O2E72204A
At His service,
Andrew
--
Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
**
Suggested Reading:
(1) http://makeashorterlink.com/?L26062048
(2) http://makeashorterlink.com/?O2F325D1A
(3) http://makeashorterlink.com/?X1C62661A
(4) http://makeashorterlink.com/?U1E13130A
(5) http://makeashorterlink.com/?K6F72510A
(6) http://makeashorterlink.com/?I24E5151A
(7) http://makeashorterlink.com/?I22222129
- Posted by Andrew B. Chung, MD/PhD
Bill wrote:
Aspirin is *not* associated with age-related neovascular macular
degeneration:
http://makeashorterlink.com/?O2E72204A
At His service,
Andrew
--
Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
**
Suggested Reading:
(1) http://makeashorterlink.com/?L26062048
(2) http://makeashorterlink.com/?O2F325D1A
(3) http://makeashorterlink.com/?X1C62661A
(4) http://makeashorterlink.com/?U1E13130A
(5) http://makeashorterlink.com/?K6F72510A
(6) http://makeashorterlink.com/?I24E5151A
(7) http://makeashorterlink.com/?I22222129
- Posted by Andrew B. Chung, MD/PhD
Bill wrote:
Aspirin is *not* associated with age-related neovascular macular
degeneration:
http://makeashorterlink.com/?O2E72204A
At His service,
Andrew
--
Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
**
Suggested Reading:
(1) http://makeashorterlink.com/?L26062048
(2) http://makeashorterlink.com/?O2F325D1A
(3) http://makeashorterlink.com/?X1C62661A
(4) http://makeashorterlink.com/?U1E13130A
(5) http://makeashorterlink.com/?K6F72510A
(6) http://makeashorterlink.com/?I24E5151A
(7) http://makeashorterlink.com/?I22222129
- Posted by Andrew B. Chung, MD/PhD
awthrawthr@yahoo.com wrote:
Not according to this recent study:
http://makeashorterlink.com/?O2E72204A
At His service,
Andrew
--
Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
**
Suggested Reading:
(1) http://makeashorterlink.com/?L26062048
(2) http://makeashorterlink.com/?O2F325D1A
(3) http://makeashorterlink.com/?X1C62661A
(4) http://makeashorterlink.com/?U1E13130A
(5) http://makeashorterlink.com/?K6F72510A
(6) http://makeashorterlink.com/?I24E5151A
(7) http://makeashorterlink.com/?I22222129
