Paraoxonase and arylesterase levels in rheumatoid arthritis.
Isik A, Koca SS, Ustundag B, Celik H, Yildirim A
Clin Rheumatol. 2007 Mar ; 26(3): 342-8
It was reported that lipid peroxidation (LPO) products increase in
rheumatoid arthritis (RA) patients and increased LPO products reduce
many antioxidants. Lipid hydroperoxides (LOOHs) are byproduct of LPO.
Paraoxonase (PON), arylesterase (ARE), free sulfhydryl (SH) groups,
and ceruloplasmin (CP) are enzymes or proteins with antioxidant
characteristics. This study aims to determine the levels of LOOHs and
SH, and the activities of PON1, ARE, and CP in RA patients. The study
included 47 active RA cases and 23 healthy volunteers. The levels of
LOOHs and SH, and the activities of PON1, ARE, and CP were determined
using appropriate methods. Student's t test and Spearman's correlation
analysis methods were employed in the statistical evaluation. The
level of LOOHs was found to be higher (p<0.001), while the level of SH
and the activities of PON1, ARE, and CP were found to be lower
(p<0.001, <0.001, <0.01, and <0.01, respectively) in the RA patient
group when compared with the control group. There was a negative
correlation between the level of LOOHs and the activity of PON1 in the
patient group (r=-0.420 and p<0.01). The results of our study indicate
increased oxidant and decreased antioxidant presence in RA patients.
PON1 and ARE are known to have antiatherosclerotic effects in addition
to their antioxidant characteristics. As the decrease in these
antioxidants, resulting from increased oxidative stress in RA
patients, development of atherosclerosis besides tissue injury seems
inevitable.
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