<<snip>>
supplementation of long-chain
polyunsaturated fatty acids may have a role in the prevention and
treatment of acute and chronic inflammatory conditions
<<snip>>
Curr Opin Clin Nutr Metab Care. 2003 Jul;6(4):413-9. Related
Articles, Links
Metabolic alterations during inflammation and its modulation by
central actions of omega-3 fatty acids.
Das UN, Ramos EJ, Meguid MM.
EFA Sciences LLC, Norwood, Massachusetts 02062, USA.
undas@efasciences.com
PURPOSE OF REVIEW: To discuss the possible relationship between long-
chain polyunsaturated fatty acids, cytokines, anandamides, nitric
oxide, leptin, various neurotransmitters in the brain, and their role
in anorexia of acute and chronic inflammatory conditions and cancer.
RECENT FINDINGS: Recent studies have shown that long-chain
polyunsaturated fatty acids, especially the omega-3 series, have
antiinflammatory actions, increase the concentrations of anandamides,
enhance the levels of acetylcholine and nitric oxide and modulate the
concentrations and actions of various neurotransmitters, including
leptin, in the brain. Patients suffering from acute and chronic
inflammatory conditions have low tissue concentrations of various
long-chain polyunsaturated fatty acids, and high levels of
proinflammatory cytokines that can cause anorexia and decrease food
intake. SUMMARY: It is suggested that supplementation of long-chain
polyunsaturated fatty acids may have a role in the prevention and
treatment of acute and chronic inflammatory conditions, improving
anorexia associated with these conditions.
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